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10.1038/ncomms14922 http://scihub22266oqcxt.onion/10.1038/ncomms14922 C5385585!5385585!28387316     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28387316&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28387316|t=2017. Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 |pdf=|usr=}}{{28387316}} gab.com Text Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28387316 #FOAvip Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion of Lkb1 (Stk11) in autochthonous and transplant models. Chromatin analysis reveals loss of H3K27me3 and gain of H3K27ac and H3K4me3 at squamous lineage genes, including Sox2, ?Np63 and Ngfr. SCC lesions have higher levels of the H3K27 methyltransferase EZH2 than the ADC lesions, but there is a clear lack of the essential Polycomb Repressive Complex 2 (PRC2) subunit EED in the SCC lesions. The pattern of high EZH2, but low H3K27me3 mark, is also prevalent in human lung SCC and SCC regions within ADSCC tumours. Using FACS-isolated populations, we demonstrate that bronchioalveolar stem cells and club cells are the likely cells-of-origin for SCC transitioned tumours. These findings shed light on the epigenetics and cellular origins of lineage-specific lung tumours. Twit Text FOAVip Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28387316 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28387316 #FOAvip English Wikipedia <ref>{{Cite pmid|28387316}}</ref> Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 #MMPMID28387316 Zhang H; Fillmore Brainson C; Koyama S; Redig AJ; Chen T; Li S; Gupta M; Garcia-de-Alba C; Paschini M; Herter-Sprie GS; Lu G; Zhang X; Marsh BP; Tuminello SJ; Xu C; Chen Z; Wang X; Akbay EA; Zheng M; Palakurthi S; Sholl LM; Rustgi AK; Kwiatkowski DJ; Diehl JA; Bass AJ; Sharpless NE; Dranoff G; Hammerman PS; Ji H; Bardeesy N; Saur D; Watanabe H; Kim CF; Wong KK Nat Commun 2017[]; 8 (ä): ä PMID28387316show ga Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion of Lkb1 (Stk11) in autochthonous and transplant models. Chromatin analysis reveals loss of H3K27me3 and gain of H3K27ac and H3K4me3 at squamous lineage genes, including Sox2, ?Np63 and Ngfr. SCC lesions have higher levels of the H3K27 methyltransferase EZH2 than the ADC lesions, but there is a clear lack of the essential Polycomb Repressive Complex 2 (PRC2) subunit EED in the SCC lesions. The pattern of high EZH2, but low H3K27me3 mark, is also prevalent in human lung SCC and SCC regions within ADSCC tumours. Using FACS-isolated populations, we demonstrate that bronchioalveolar stem cells and club cells are the likely cells-of-origin for SCC transitioned tumours. These findings shed light on the epigenetics and cellular origins of lineage-specific lung tumours. äLkb1 inactivation drives lung cancer lineage switching governed by Pol(epmc).pdf DeepDyve Pubget Overpricing