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10.3748/wjg.v23.i13.2330 http://scihub22266oqcxt.onion/10.3748/wjg.v23.i13.2330 C5385399!5385399!28428712     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Gastroenterol 2017 ; 23 (13): 2330-6 Nephropedia Template TP {{tp|p=28428712|t=2017. Notch signaling mediated by TGF-?/Smad pathway in concanavalin A-induced liver fibrosis in rats |pdf=|usr=}}{{28428712}} gab.com Text Notch signaling mediated by TGF- /Smad pathway in concanavalin A-induced liver fibrosis in rats JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28428712 #FOAvip AIM: To explore the exact interaction between Notch and transforming growth factor (TGF)-? signaling in liver fibrosis. METHODS: We established a rat model of liver fibrosis induced by concanavalin A. Peripheral blood mononuclear cells (PBMCs) were isolated from the modeled rats, and cultured with ?-secretase inhibitor DAPT and TGF-? inhibitor for 24 h. The mRNA levels of Notch and TGF-? signaling were detected by quantitative real-time polymerase chain reaction. Expression of Notch and TGF-? proteins was analyzed by western blotting. RESULTS: Compared to control rats, Notch and TGF-? signaling was activated in PBMCs of model rats. Administration of DAPT and TGF-? inhibitor suppressed Notch and TGF-? signal transducer in PBMCs of model rats. DAPT reduced mRNA and protein expression of TGF-? signaling, such as TGF-?1 and Smad3. TGF-? inhibitor also downregulated Notch1, Hes1 and Hes5, and mRNA and protein expression of the Notch signaling pathway. CONCLUSION: Notch and TGF-? signaling play a role in liver fibrosis. TGF-? signaling upregulates Notch signaling, which promotes TGF-? signaling. Twit Text FOAVip Notch signaling mediated by TGF- /Smad pathway in concanavalin A-induced liver fibrosis in rats ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28428712 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28428712 #FOAvip English Wikipedia <ref>{{Cite pmid|28428712}}</ref> Notch signaling mediated by TGF-?/Smad pathway in concanavalin A-induced liver fibrosis in rats #MMPMID28428712 Wang Y; Shen RW; Han B; Li Z; Xiong L; Zhang FY; Cong BB; Zhang B World J Gastroenterol 2017[Apr]; 23 (13): 2330-6 PMID28428712show ga AIM: To explore the exact interaction between Notch and transforming growth factor (TGF)-? signaling in liver fibrosis. METHODS: We established a rat model of liver fibrosis induced by concanavalin A. Peripheral blood mononuclear cells (PBMCs) were isolated from the modeled rats, and cultured with ?-secretase inhibitor DAPT and TGF-? inhibitor for 24 h. The mRNA levels of Notch and TGF-? signaling were detected by quantitative real-time polymerase chain reaction. Expression of Notch and TGF-? proteins was analyzed by western blotting. RESULTS: Compared to control rats, Notch and TGF-? signaling was activated in PBMCs of model rats. Administration of DAPT and TGF-? inhibitor suppressed Notch and TGF-? signal transducer in PBMCs of model rats. DAPT reduced mRNA and protein expression of TGF-? signaling, such as TGF-?1 and Smad3. TGF-? inhibitor also downregulated Notch1, Hes1 and Hes5, and mRNA and protein expression of the Notch signaling pathway. CONCLUSION: Notch and TGF-? signaling play a role in liver fibrosis. TGF-? signaling upregulates Notch signaling, which promotes TGF-? signaling. äNotch signaling mediated by TGF-?/Smad pathway in concanavalin A-induc(epmc).pdf DeepDyve Pubget Overpricing