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10.1038/nrm.2016.43 http://scihub22266oqcxt.onion/10.1038/nrm.2016.43 C5385261!5385261!27165790     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Mol+Cell+Biol 2016 ; 17 (6): 364-78 Nephropedia Template TP {{tp|p=27165790|t=2016. Stop pulling my strings ? what telomeres taught us about the DNA damage response |pdf=|usr=}}{{27165790}} gab.com Text Stop pulling my strings what telomeres taught us about the DNA damage response JO: Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27165790 #FOAvip Mammalian cells have evolved specialized mechanisms to sense and repair double-strand breaks (DSBs) to maintain genomic stability. However, in certain cases, the activity of these pathways can lead to aberrant DNA repair, genomic instability and tumorigenesis. One such case is DNA repair at the natural ends of linear chromosomes, known as telomeres, which can lead to chromosome-end fusions. Here, we review data obtained over the past decade and discuss the mechanisms that protect mammalian chromosome ends from the DNA damage response. We also discuss how telomere research has helped to uncover key steps in DSB repair. Last, we summarize how dysfunctional telomeres and the ensuing genomic instability drive the progression of cancer. Twit Text FOAVip Stop pulling my strings what telomeres taught us about the DNA damage response ????Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27165790 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27165790 #FOAvip English Wikipedia <ref>{{Cite pmid|27165790}}</ref> Stop pulling my strings ? what telomeres taught us about the DNA damage response #MMPMID27165790 Lazzerini-Denchi E; Sfeir A Nat Rev Mol Cell Biol 2016[Jun]; 17 (6): 364-78 PMID27165790show ga Mammalian cells have evolved specialized mechanisms to sense and repair double-strand breaks (DSBs) to maintain genomic stability. However, in certain cases, the activity of these pathways can lead to aberrant DNA repair, genomic instability and tumorigenesis. One such case is DNA repair at the natural ends of linear chromosomes, known as telomeres, which can lead to chromosome-end fusions. Here, we review data obtained over the past decade and discuss the mechanisms that protect mammalian chromosome ends from the DNA damage response. We also discuss how telomere research has helped to uncover key steps in DSB repair. Last, we summarize how dysfunctional telomeres and the ensuing genomic instability drive the progression of cancer. äStop pulling my strings ? what telomeres taught us about the DNA damag(epmc).pdf DeepDyve Pubget Overpricing