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10.1016/j.neuropharm.2017.01.007 http://scihub22266oqcxt.onion/10.1016/j.neuropharm.2017.01.007 C5385150!5385150 !28088358     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28088358 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neuropharmacology 2017 ; 116 (ä): 364-370 Nephropedia Template TP {{tp|p=28088358 |t=2017. The peroxisome proliferator-activated receptor alpha agonist fenofibrate attenuates alcohol self-administration in rats |pdf=|usr=}}{{28088358 }} gab.com Text The peroxisome proliferator-activated receptor alpha agonist fenofibrate attenuates alcohol self-administration in rats JO: Neuropharmacology http://www.kidney.de/pget.php?&tw=1&pmid=28088358 #FOAvip Fibrates are a class of medications used to treat hypercholesterolemia and dyslipidemia that target nuclear peroxisome proliferator-activated receptors (PPARs). Studies have shown the PPAR? agonist fenofibrate decreases voluntary EtOH consumption however its impact on the reinforcing and motivational effects of EtOH is unknown. We evaluated the ability of fenofibrate (25, 50 and 100 mg/kg), to alter EtOH (10%, w/v) and sucrose (2%, w/v) operant self-administration in rats under a FR2 schedule of reinforcement over four days and under a progressive ratio (PR) schedule on day five of treatment. Results showed fenofibrate dose-dependently decreased EtOH self-administration under both schedules of reinforcement with the greatest effects seen after four to five days of treatment. Fenofibrate decreased responding for sucrose only under the PR schedule of reinforcement and this effect was not dose-dependent. These findings provide further evidence for fenofibrate as a potential treatment for alcohol use disorder in humans. Twit Text FOAVip The peroxisome proliferator-activated receptor alpha agonist fenofibrate attenuates alcohol self-administration in rats ????Neuropharmacology http://www.kidney.de/pget.php?&tw=1&pmid=28088358 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28088358 #FOAvip English Wikipedia <ref>{{Cite pmid|28088358 }}</ref> The peroxisome proliferator-activated receptor alpha agonist fenofibrate attenuates alcohol self-administration in rats #MMPMID28088358 Haile CN ; Kosten TA Neuropharmacology 2017[Apr]; 116 (ä): 364-370 PMID28088358 show ga Fibrates are a class of medications used to treat hypercholesterolemia and dyslipidemia that target nuclear peroxisome proliferator-activated receptors (PPARs). Studies have shown the PPAR? agonist fenofibrate decreases voluntary EtOH consumption however its impact on the reinforcing and motivational effects of EtOH is unknown. We evaluated the ability of fenofibrate (25, 50 and 100 mg/kg), to alter EtOH (10%, w/v) and sucrose (2%, w/v) operant self-administration in rats under a FR2 schedule of reinforcement over four days and under a progressive ratio (PR) schedule on day five of treatment. Results showed fenofibrate dose-dependently decreased EtOH self-administration under both schedules of reinforcement with the greatest effects seen after four to five days of treatment. Fenofibrate decreased responding for sucrose only under the PR schedule of reinforcement and this effect was not dose-dependent. These findings provide further evidence for fenofibrate as a potential treatment for alcohol use disorder in humans. |Alcohol Deterrents/*pharmacology [MESH] |Alcoholism/*drug therapy/metabolism [MESH] |Animals [MESH] |Central Nervous System Depressants/administration & dosage [MESH] |Conditioning, Operant/drug effects/physiology [MESH] |Dietary Sucrose [MESH] |Dose-Response Relationship, Drug [MESH] |Ethanol/administration & dosage [MESH] |Fenofibrate/*pharmacology [MESH] |PPAR alpha/*agonists/metabolism [MESH] |Rats, Wistar [MESH] |Reinforcement Schedule [MESH]The peroxisome proliferator-activated receptor alpha agonist fenofibra(epmc).pdf DeepDyve Pubget Overpricing