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10.1038/nature21429 http://scihub22266oqcxt.onion/10.1038/nature21429 C5385134!5385134!28289288     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2017 ; 544 (7648): 59-64 Nephropedia Template TP {{tp|p=28289288|t=2017. 3D structure of individual mammalian genomes studied by single cell Hi-C |pdf=|usr=}}{{28289288}} gab.com Text 3D structure of individual mammalian genomes studied by single cell Hi-C JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=28289288 #FOAvip The folding of genomic DNA from the beads-on-a-string like structure of nucleosomes into higher order assemblies is critically linked to nuclear processes. We have calculated the first 3D structures of entire mammalian genomes using data from a new chromosome conformation capture procedure that allows us to first image and then process single cells. This has allowed us to study genome folding down to a scale of <100 kb and to validate the structures. We show that the structures of individual topological-associated domains and loops vary very substantially from cell-to-cell. By contrast, A/B compartments, lamin-associated domains and active enhancers/promoters are organized in a consistent way on a genome-wide basis in every cell, suggesting that they could drive chromosome and genome folding. Through studying pluripotency factor- and NuRD-regulated genes, we illustrate how single cell genome structure determination provides a novel approach for investigating biological processes. Twit Text FOAVip 3D structure of individual mammalian genomes studied by single cell Hi-C ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=28289288 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28289288 #FOAvip English Wikipedia <ref>{{Cite pmid|28289288}}</ref> 3D structure of individual mammalian genomes studied by single cell Hi-C #MMPMID28289288 Stevens TJ; Lando D; Basu S; Atkinson LP; Cao Y; Lee SF; Leeb M; Wohlfahrt KJ; Boucher W; O?Shaughnessy-Kirwan A; Cramard J; Faure AJ; Ralser M; Blanco E; Morey L; Sansó M; Palayret MGS; Lehner B; Di Croce L; Wutz A; Hendrich B; Klenerman D; Laue ED Nature 2017[Apr]; 544 (7648): 59-64 PMID28289288show ga The folding of genomic DNA from the beads-on-a-string like structure of nucleosomes into higher order assemblies is critically linked to nuclear processes. We have calculated the first 3D structures of entire mammalian genomes using data from a new chromosome conformation capture procedure that allows us to first image and then process single cells. This has allowed us to study genome folding down to a scale of <100 kb and to validate the structures. We show that the structures of individual topological-associated domains and loops vary very substantially from cell-to-cell. By contrast, A/B compartments, lamin-associated domains and active enhancers/promoters are organized in a consistent way on a genome-wide basis in every cell, suggesting that they could drive chromosome and genome folding. Through studying pluripotency factor- and NuRD-regulated genes, we illustrate how single cell genome structure determination provides a novel approach for investigating biological processes. ä3D structure of individual mammalian genomes studied by single cell Hi(epmc).pdf DeepDyve Pubget Overpricing