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10.2147/DDDT.S129419 http://scihub22266oqcxt.onion/10.2147/DDDT.S129419 C5384716!5384716!28408801     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28408801&cmd=llinks): Failed to open stream: HTTP request failed! 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Effects of ?-d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, ROR?t, IL4 and GATA3 gene expressions in rheumatoid arthritis patients |pdf=|usr=}}{{28408801}} gab.com Text Effects of -d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, ROR t, IL4 and GATA3 gene expressions in rheumatoid arthritis patients JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=28408801 #FOAvip Rheumatoid arthritis (RA) is the most common form of chronic inflammatory arthritis characterized by pain, swelling and destruction of joints, with a resultant disability. Disease-modifying anti-rheumatic drugs (DMARDs) and biological drugs can interfere with the disease process. In this study, the effect of ?-d-mannuronic acid (M2000) as a novel non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive and anti-inflammatory effects together with antioxidant effects was evaluated on IL17, ROR?t, IL4 and GATA3 gene expression in 12 RA patients. Previously, M2000 driven from sodium alginate (natural product; patented, DEU: 102016113018.4) has shown a notable efficacy in experimental models of multiple sclerosis, RA and nephrotic syndrome. This study was performed on 12 patients with RA who had an inadequate response to conventional treatments. During this trial, patients were permitted to continue the conventional therapy excluding NSAIDs. M2000 was administered orally at a dose of 500 mg twice daily for 12 weeks. The peripheral blood mononuclear cells (PBMCs) were collected before and after treatment to evaluate the expression levels of IL4, GATA3, IL17 and ROR?t. The gene expression results showed that M2000 has a potent efficacy, so that it could not only significantly decrease IL17 and ROR?t levels but also increase IL4 and GATA3 levels after 12 weeks of treatment. Moreover, the gene expression results were in accordance with the clinical and preclinical assessments. In conclusion, M2000 as a natural novel agent has therapeutic and immunosuppressive properties on RA patients (identifier: IRCT2014011213739N2). Twit Text FOAVip Effects of -d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, ROR t, IL4 and GATA3 gene expressions in rheumatoid arthritis patients ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=28408801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28408801 #FOAvip English Wikipedia <ref>{{Cite pmid|28408801}}</ref> Effects of ?-d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, ROR?t, IL4 and GATA3 gene expressions in rheumatoid arthritis patients #MMPMID28408801 Barati A; Jamshidi AR; Ahmadi H; Aghazadeh Z; Mirshafiey A Drug Des Devel Ther 2017[]; 11 (ä): 1027-33 PMID28408801show ga Rheumatoid arthritis (RA) is the most common form of chronic inflammatory arthritis characterized by pain, swelling and destruction of joints, with a resultant disability. Disease-modifying anti-rheumatic drugs (DMARDs) and biological drugs can interfere with the disease process. In this study, the effect of ?-d-mannuronic acid (M2000) as a novel non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive and anti-inflammatory effects together with antioxidant effects was evaluated on IL17, ROR?t, IL4 and GATA3 gene expression in 12 RA patients. Previously, M2000 driven from sodium alginate (natural product; patented, DEU: 102016113018.4) has shown a notable efficacy in experimental models of multiple sclerosis, RA and nephrotic syndrome. This study was performed on 12 patients with RA who had an inadequate response to conventional treatments. During this trial, patients were permitted to continue the conventional therapy excluding NSAIDs. M2000 was administered orally at a dose of 500 mg twice daily for 12 weeks. The peripheral blood mononuclear cells (PBMCs) were collected before and after treatment to evaluate the expression levels of IL4, GATA3, IL17 and ROR?t. The gene expression results showed that M2000 has a potent efficacy, so that it could not only significantly decrease IL17 and ROR?t levels but also increase IL4 and GATA3 levels after 12 weeks of treatment. Moreover, the gene expression results were in accordance with the clinical and preclinical assessments. In conclusion, M2000 as a natural novel agent has therapeutic and immunosuppressive properties on RA patients (identifier: IRCT2014011213739N2). äEffects of ?-d-mannuronic acid, as a novel non-steroidal anti-inflamma(epmc).pdf DeepDyve Pubget Overpricing