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10.2147/OTT.S126905 http://scihub22266oqcxt.onion/10.2147/OTT.S126905 C5384685!5384685 !28408840     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28408840 &cmd=llinks): Failed to open stream: HTTP request failed! 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Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis |pdf=|usr=}}{{28408840 }} gab.com Text Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis JO: Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=28408840 #FOAvip BACKGROUND: The prognostic and predictive significance of the high-level microsatellite instability (MSI-H) phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting. PATIENTS AND METHODS: A retrospective analysis of MSI-H cancer patient files was conducted. We analyzed the genetic data, clinical characteristics, and oncological treatments, including chemotherapy and surgical interventions. RESULTS: Clinical data of 73 MSI-H cancer patients were available. Mean age at diagnosis of first malignancy was 52.3 years. Eight patients (11%) had more than four malignancies each. Most patients (76%) had colorectal cancer (CRC). Seventeen patients (23%) had only extracolonic malignancies. Eighteen women (36%) had gynecological malignancy. Nine women (18%) had breast cancer. Mean follow-up was 8.5 years. Five-year overall survival and disease-free survival of all MSI-H cancer patients from first malignancy were 86% and 74.6%, respectively. Five-year overall survival rates of stage 2, 3, and 4 MSI-H CRC patients were 89.5%, 58.4%, and 22.9%, respectively. CONCLUSION: Although the overall prognosis of MSI-H cancer patients is favorable, this advantage may not be maintained in advanced MSI-H CRC patients. Twit Text FOAVip Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis ????Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=28408840 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28408840 #FOAvip English Wikipedia <ref>{{Cite pmid|28408840 }}</ref> Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis #MMPMID28408840 Halpern N ; Goldberg Y ; Kadouri L ; Duvdevani M ; Hamburger T ; Peretz T ; Hubert A Onco Targets Ther 2017[]; 10 (ä): 1889-1896 PMID28408840 show ga BACKGROUND: The prognostic and predictive significance of the high-level microsatellite instability (MSI-H) phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting. PATIENTS AND METHODS: A retrospective analysis of MSI-H cancer patient files was conducted. We analyzed the genetic data, clinical characteristics, and oncological treatments, including chemotherapy and surgical interventions. RESULTS: Clinical data of 73 MSI-H cancer patients were available. Mean age at diagnosis of first malignancy was 52.3 years. Eight patients (11%) had more than four malignancies each. Most patients (76%) had colorectal cancer (CRC). Seventeen patients (23%) had only extracolonic malignancies. Eighteen women (36%) had gynecological malignancy. Nine women (18%) had breast cancer. Mean follow-up was 8.5 years. Five-year overall survival and disease-free survival of all MSI-H cancer patients from first malignancy were 86% and 74.6%, respectively. Five-year overall survival rates of stage 2, 3, and 4 MSI-H CRC patients were 89.5%, 58.4%, and 22.9%, respectively. CONCLUSION: Although the overall prognosis of MSI-H cancer patients is favorable, this advantage may not be maintained in advanced MSI-H CRC patients. äClinical course and outcome of patients with high-level microsatellite(epmc).pdf DeepDyve Pubget Overpricing