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10.1038/cti.2016.82 http://scihub22266oqcxt.onion/10.1038/cti.2016.82 C5384286!5384286!28435673     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Transl+Immunology 2016 ; 5 (12): e122- Nephropedia Template TP {{tp|p=28435673|t=2016. Primate autoimmune disease models; lost for translation?|pdf=|usr=}}{{28435673}} gab.com Text Primate autoimmune disease models; lost for translation JO: Clin Transl Immunology http://www.kidney.de/pget.php?&tw=1&pmid=28435673 #FOAvip Replacement, reduction and refinement (the 3R's) are the leading principles in translational research with animals. To be useful a model should also be clinically Relevant (the 4th R). Work in a non-human primate model of multiple sclerosis, the experimental autoimmune encephalomyelitis model, reveals an inherent conflict among these 4R principles. The impossibility to harmonize all 4R's forms a major challenge when the model is applied in preclinical drug development. Twit Text FOAVip Primate autoimmune disease models; lost for translation ????Clin Transl Immunology http://www.kidney.de/pget.php?&tw=1&pmid=28435673 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28435673 #FOAvip English Wikipedia <ref>{{Cite pmid|28435673}}</ref> Primate autoimmune disease models; lost for translation? #MMPMID28435673 't Hart BA Clin Transl Immunology 2016[Dec]; 5 (12): e122- PMID28435673show ga Replacement, reduction and refinement (the 3R's) are the leading principles in translational research with animals. To be useful a model should also be clinically Relevant (the 4th R). Work in a non-human primate model of multiple sclerosis, the experimental autoimmune encephalomyelitis model, reveals an inherent conflict among these 4R principles. The impossibility to harmonize all 4R's forms a major challenge when the model is applied in preclinical drug development. äPrimate autoimmune disease models; lost for translation?(epmc).pdf DeepDyve Pubget Overpricing