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10.1038/srep46101 http://scihub22266oqcxt.onion/10.1038/srep46101 C5384238!5384238!28387377     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28387377|t=2017. Novel miRNA-mRNA interactions conserved in essential cancer pathways |pdf=|usr=}}{{28387377}} gab.com Text Novel miRNA-mRNA interactions conserved in essential cancer pathways JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28387377 #FOAvip Cancer is a complex disease in which unrestrained cell proliferation results in tumour development. Extensive research into the molecular mechanisms underlying tumorigenesis has led to the characterization of oncogenes and tumour suppressors that are key elements in cancer growth and progression, as well as that of other important elements like microRNAs. These genes and miRNAs appear to be constitutively deregulated in cancer. To identify signatures of miRNA-mRNA interactions potentially conserved in essential cancer pathways, we have conducted an integrative analysis of transcriptomic data, also taking into account methylation and copy number alterations. We analysed 18,605 raw transcriptome samples from The Cancer Genome Atlas covering 15 of the most common types of human tumours. From this global transcriptome study, we recovered known cancer-associated miRNA-targets and importantly, we identified new potential targets from miRNA families, also analysing the phenotypic outcomes of these genes/mRNAs in terms of survival. Further analyses could lead to novel approaches in cancer therapy. Twit Text FOAVip Novel miRNA-mRNA interactions conserved in essential cancer pathways ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28387377 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28387377 #FOAvip English Wikipedia <ref>{{Cite pmid|28387377}}</ref> Novel miRNA-mRNA interactions conserved in essential cancer pathways #MMPMID28387377 Andrés-León E; Cases I; Alonso S; Rojas AM Sci Rep 2017[]; 7 (ä): ä PMID28387377show ga Cancer is a complex disease in which unrestrained cell proliferation results in tumour development. Extensive research into the molecular mechanisms underlying tumorigenesis has led to the characterization of oncogenes and tumour suppressors that are key elements in cancer growth and progression, as well as that of other important elements like microRNAs. These genes and miRNAs appear to be constitutively deregulated in cancer. To identify signatures of miRNA-mRNA interactions potentially conserved in essential cancer pathways, we have conducted an integrative analysis of transcriptomic data, also taking into account methylation and copy number alterations. We analysed 18,605 raw transcriptome samples from The Cancer Genome Atlas covering 15 of the most common types of human tumours. From this global transcriptome study, we recovered known cancer-associated miRNA-targets and importantly, we identified new potential targets from miRNA families, also analysing the phenotypic outcomes of these genes/mRNAs in terms of survival. Further analyses could lead to novel approaches in cancer therapy. äNovel miRNA-mRNA interactions conserved in essential cancer pathways (epmc).pdf DeepDyve Pubget Overpricing