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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP
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OncoScore: a novel, Internet-based tool to assess the oncogenic potential of genes #MMPMID28387367
Rocco P; Daniele R; Roberta S; Alessandra P; Luca DS; Pierangelo F; Vera M; Nicoletta C; Nitesh S; Carlo GP
Sci Rep 2017[]; 7 (ä): ä PMID28387367show ga
The complicated, evolving landscape of cancer mutations poses a formidable challenge to identify cancer genes among the large lists of mutations typically generated in NGS experiments. The ability to prioritize these variants is therefore of paramount importance. To address this issue we developed OncoScore, a text-mining tool that ranks genes according to their association with cancer, based on available biomedical literature. Receiver operating characteristic curve and the area under the curve (AUC) metrics on manually curated datasets confirmed the excellent discriminating capability of OncoScore (OncoScore cut-off threshold?=?21.09; AUC?=?90.3%, 95% CI: 88.1?92.5%), indicating that OncoScore provides useful results in cases where an efficient prioritization of cancer-associated genes is needed.