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10.1038/ncomms14825

http://scihub22266oqcxt.onion/10.1038/ncomms14825
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C5384229!5384229!28382969
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suck abstract from ncbi


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pmid28382969      Nat+Commun 2017 ; 8 (ä): ä
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  • Sensitive detection of rare disease-associated cell subsets via representation learning #MMPMID28382969
  • Arvaniti E; Claassen M
  • Nat Commun 2017[]; 8 (ä): ä PMID28382969show ga
  • Rare cell populations play a pivotal role in the initiation and progression of diseases such as cancer. However, the identification of such subpopulations remains a difficult task. This work describes CellCnn, a representation learning approach to detect rare cell subsets associated with disease using high-dimensional single-cell measurements. Using CellCnn, we identify paracrine signalling-, AIDS onset- and rare CMV infection-associated cell subsets in peripheral blood, and extremely rare leukaemic blast populations in minimal residual disease-like situations with frequencies as low as 0.01%.
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