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10.1038/ncomms14979 http://scihub22266oqcxt.onion/10.1038/ncomms14979 C5384228!5384228 !28382931     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28382931 &cmd=llinks): Failed to open stream: HTTP request failed! 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Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade |pdf=|usr=}}{{28382931 }} gab.com Text Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28382931 #FOAvip It is widely accepted that dynamic and reversible tumour cell plasticity is required for metastasis, however, in vivo steps and molecular mechanisms are poorly elucidated. We demonstrate here that monocytic (mMDSC) and granulocytic (gMDSC) subsets of myeloid-derived suppressor cells infiltrate in the primary tumour and distant organs with different time kinetics and regulate spatiotemporal tumour plasticity. Using co-culture experiments and mouse transcriptome analyses in syngeneic mouse models, we provide evidence that tumour-infiltrated mMDSCs facilitate tumour cell dissemination from the primary site by inducing EMT/CSC phenotype. In contrast, pulmonary gMDSC infiltrates support the metastatic growth by reverting EMT/CSC phenotype and promoting tumour cell proliferation. Furthermore, lung-derived gMDSCs isolated from tumour-bearing animals enhance metastatic growth of already disseminated tumour cells. MDSC-induced 'metastatic gene signature' derived from murine syngeneic model predicts poor patient survival in the majority of human solid tumours. Thus spatiotemporal MDSC infiltration may have clinical implications in tumour progression. Twit Text FOAVip Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28382931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28382931 #FOAvip English Wikipedia <ref>{{Cite pmid|28382931 }}</ref> Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade #MMPMID28382931 Ouzounova M ; Lee E ; Piranlioglu R ; El Andaloussi A ; Kolhe R ; Demirci MF ; Marasco D ; Asm I ; Chadli A ; Hassan KA ; Thangaraju M ; Zhou G ; Arbab AS ; Cowell JK ; Korkaya H Nat Commun 2017[Apr]; 8 (ä): 14979 PMID28382931 show ga It is widely accepted that dynamic and reversible tumour cell plasticity is required for metastasis, however, in vivo steps and molecular mechanisms are poorly elucidated. We demonstrate here that monocytic (mMDSC) and granulocytic (gMDSC) subsets of myeloid-derived suppressor cells infiltrate in the primary tumour and distant organs with different time kinetics and regulate spatiotemporal tumour plasticity. Using co-culture experiments and mouse transcriptome analyses in syngeneic mouse models, we provide evidence that tumour-infiltrated mMDSCs facilitate tumour cell dissemination from the primary site by inducing EMT/CSC phenotype. In contrast, pulmonary gMDSC infiltrates support the metastatic growth by reverting EMT/CSC phenotype and promoting tumour cell proliferation. Furthermore, lung-derived gMDSCs isolated from tumour-bearing animals enhance metastatic growth of already disseminated tumour cells. MDSC-induced 'metastatic gene signature' derived from murine syngeneic model predicts poor patient survival in the majority of human solid tumours. Thus spatiotemporal MDSC infiltration may have clinical implications in tumour progression. |Animals [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/genetics [MESH] |Cells, Cultured [MESH] |Female [MESH] |Gene Expression Profiling/*methods [MESH] |Granulocytes/*metabolism [MESH] |Humans [MESH] |Mammary Neoplasms, Experimental/genetics/metabolism/pathology [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Monocytes/*metabolism [MESH] |Myeloid-Derived Suppressor Cells/*metabolism [MESH] |Neoplasm Metastasis [MESH]Monocytic and granulocytic myeloid derived suppressor cells differenti(epmc).pdf DeepDyve Pubget Overpricing