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10.1038/ncomms14911 http://scihub22266oqcxt.onion/10.1038/ncomms14911 C5384227!5384227!28382966     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28382966.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28382966|t=2017. The Pu 1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger |pdf=|usr=}}{{28382966}} gab.com Text The Pu 1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28382966 #FOAvip In response to infection and injury, the neutrophil population rapidly expands and then quickly re-establishes the basal state when inflammation resolves. The exact pathways governing neutrophil/macrophage lineage outputs from a common granulocyte-macrophage progenitor are still not completely understood. From a forward genetic screen in zebrafish, we identify the transcriptional repressor, ZBTB11, as critical for basal and emergency granulopoiesis. ZBTB11 sits in a pathway directly downstream of master myeloid regulators including PU.1, and TP53 is one direct ZBTB11 transcriptional target. TP53 repression is dependent on ZBTB11 cys116, which is a functionally critical, metal ion-coordinating residue within a novel viral integrase-like zinc finger domain. To our knowledge, this is the first description of a function for this domain in a cellular protein. We demonstrate that the PU.1?ZBTB11?TP53 pathway is conserved from fish to mammals. Finally, Zbtb11 mutant rescue experiments point to a ZBTB11-regulated TP53 requirement in development of other organs. Twit Text FOAVip The Pu 1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28382966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28382966 #FOAvip English Wikipedia <ref>{{Cite pmid|28382966}}</ref> The Pu 1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger #MMPMID28382966 Keightley MC; Carradice DP; Layton JE; Pase L; Bertrand JY; Wittig JG; Dakic A; Badrock AP; Cole NJ; Traver D; Nutt SL; McCoey J; Buckle AM; Heath JK; Lieschke GJ Nat Commun 2017[]; 8 (ä): ä PMID28382966show ga In response to infection and injury, the neutrophil population rapidly expands and then quickly re-establishes the basal state when inflammation resolves. The exact pathways governing neutrophil/macrophage lineage outputs from a common granulocyte-macrophage progenitor are still not completely understood. From a forward genetic screen in zebrafish, we identify the transcriptional repressor, ZBTB11, as critical for basal and emergency granulopoiesis. ZBTB11 sits in a pathway directly downstream of master myeloid regulators including PU.1, and TP53 is one direct ZBTB11 transcriptional target. TP53 repression is dependent on ZBTB11 cys116, which is a functionally critical, metal ion-coordinating residue within a novel viral integrase-like zinc finger domain. To our knowledge, this is the first description of a function for this domain in a cellular protein. We demonstrate that the PU.1?ZBTB11?TP53 pathway is conserved from fish to mammals. Finally, Zbtb11 mutant rescue experiments point to a ZBTB11-regulated TP53 requirement in development of other organs. äThe Pu 1 target gene Zbtb11 regulates neutrophil development through i(epmc).pdf DeepDyve Pubget Overpricing