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10.1038/ncomms14911 http://scihub22266oqcxt.onion/10.1038/ncomms14911 C5384227!5384227 !28382966     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28382966 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Pu 1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger |pdf=|usr=}}{{28382966 }} gab.com Text The Pu 1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28382966 #FOAvip In response to infection and injury, the neutrophil population rapidly expands and then quickly re-establishes the basal state when inflammation resolves. The exact pathways governing neutrophil/macrophage lineage outputs from a common granulocyte-macrophage progenitor are still not completely understood. From a forward genetic screen in zebrafish, we identify the transcriptional repressor, ZBTB11, as critical for basal and emergency granulopoiesis. ZBTB11 sits in a pathway directly downstream of master myeloid regulators including PU.1, and TP53 is one direct ZBTB11 transcriptional target. TP53 repression is dependent on ZBTB11 cys116, which is a functionally critical, metal ion-coordinating residue within a novel viral integrase-like zinc finger domain. To our knowledge, this is the first description of a function for this domain in a cellular protein. We demonstrate that the PU.1-ZBTB11-TP53 pathway is conserved from fish to mammals. Finally, Zbtb11 mutant rescue experiments point to a ZBTB11-regulated TP53 requirement in development of other organs. Twit Text FOAVip The Pu 1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28382966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28382966 #FOAvip English Wikipedia <ref>{{Cite pmid|28382966 }}</ref> The Pu 1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger #MMPMID28382966 Keightley MC ; Carradice DP ; Layton JE ; Pase L ; Bertrand JY ; Wittig JG ; Dakic A ; Badrock AP ; Cole NJ ; Traver D ; Nutt SL ; McCoey J ; Buckle AM ; Heath JK ; Lieschke GJ Nat Commun 2017[Apr]; 8 (ä): 14911 PMID28382966 show ga In response to infection and injury, the neutrophil population rapidly expands and then quickly re-establishes the basal state when inflammation resolves. The exact pathways governing neutrophil/macrophage lineage outputs from a common granulocyte-macrophage progenitor are still not completely understood. From a forward genetic screen in zebrafish, we identify the transcriptional repressor, ZBTB11, as critical for basal and emergency granulopoiesis. ZBTB11 sits in a pathway directly downstream of master myeloid regulators including PU.1, and TP53 is one direct ZBTB11 transcriptional target. TP53 repression is dependent on ZBTB11 cys116, which is a functionally critical, metal ion-coordinating residue within a novel viral integrase-like zinc finger domain. To our knowledge, this is the first description of a function for this domain in a cellular protein. We demonstrate that the PU.1-ZBTB11-TP53 pathway is conserved from fish to mammals. Finally, Zbtb11 mutant rescue experiments point to a ZBTB11-regulated TP53 requirement in development of other organs. |*Neutrophils [MESH] |Animals [MESH] |Animals, Genetically Modified [MESH] |Databases, Protein [MESH] |Leukopoiesis/*genetics [MESH] |Proto-Oncogene Proteins/*metabolism [MESH] |Repressor Proteins/*genetics [MESH] |Signal Transduction [MESH] |Trans-Activators/*metabolism [MESH] |Tumor Suppressor Protein p53/*metabolism [MESH] |Zebrafish [MESH] |Zebrafish Proteins/*genetics [MESH]The Pu 1 target gene Zbtb11 regulates neutrophil development through i(epmc).pdf DeepDyve Pubget Overpricing