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2017 ; 7
(ä): 46036
Nephropedia Template TP
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English Wikipedia
Cost-Effectiveness of Administering Rituximab for Steroid-Dependent Nephrotic
Syndrome and Frequently Relapsing Nephrotic Syndrome: A Preliminary Study in
Japan
#MMPMID28387313
Takura T
; Takei T
; Nitta K
Sci Rep
2017[Apr]; 7
(ä): 46036
PMID28387313
show ga
With regard to the use of rituximab for patients with steroid-dependent nephrotic
syndrome and frequently relapsing nephrotic syndrome, not only has the regimen
not been clinically verified but also there is a lack of health economics
evidence. Therefore, we conducted a prospective clinical study on 30 patients
before (with steroids and immunosuppressants) and after introducing rituximab
therapy. Relapse rates and total invoiced medical expenses were selected as the
primary endpoints for treatment effectiveness and treatment costs, respectively.
As secondary endpoints, cost-effectiveness was compared before and after
administering rituximab in relation to previous pharmacotherapy. The observation
period was 24 months before and after the initiation of rituximab. We showed that
there was a statistically significant improvement in the relapse rate from a mean
of 4.30 events before administration to a mean of 0.27 events after
administration and that there was a significantly better prognosis in the
cumulative avoidance of relapse rate by Kaplan-Meier analysis (p?0.01).
Finally, the total medical costs decreased from 2,923?USD to 1,280?USD per month,
and the pre-post cost-effectiveness was confirmed as dominant. We, therefore,
conclude that treatment with rituximab was possibly superior to previous
pharmacological treatments from a health economics perspective.
|*Cost-Benefit Analysis
[MESH]
|Adult
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Japan
[MESH]
|Kaplan-Meier Estimate
[MESH]
|Male
[MESH]
|Nephrotic Syndrome/*drug therapy/urine
[MESH]
|Recurrence
[MESH]
|Rituximab/*administration & dosage/*economics/therapeutic use
[MESH]