Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/cdd.2016.162 http://scihub22266oqcxt.onion/10.1038/cdd.2016.162 C5384023!5384023!28186502     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2017 ; 24 (4): 660-71 Nephropedia Template TP {{tp|p=28186502|t=2017. STAT1 mediates transmembrane TNF-alpha-induced formation of death-inducing signaling complex and apoptotic signaling via TNFR1 |pdf=|usr=}}{{28186502}} gab.com Text STAT1 mediates transmembrane TNF-alpha-induced formation of death-inducing signaling complex and apoptotic signaling via TNFR1 JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=28186502 #FOAvip Tumor necrosis factor-alpha (TNF-?) exists in two forms: secretory TNF-? (sTNF-?) and transmembrane TNF-? (tmTNF-?). Although both forms of TNF-? induce tumor cell apoptosis, tmTNF-? is able to kill tumor cells that are resistant to sTNF-?-mediated cytotoxicity, indicating their differences in signal transduction. Here, we demonstrate that internalization of TNFR1 is crucial for sTNF-?- but not for tmTNF-?-induced apoptosis. sTNF-? induces binding of tumor necrosis factor receptor type 1-associated death domain protein (TRADD) to the death domain (DD) of TNFR1 and subsequent activation of nuclear factor kappa B (NF-?B), and the formation of death-inducing signaling complexes (DISCs) in the cytoplasm after internalization. In contrast, tmTNF-? induces DISC formation on the membrane in a DD-independent manner. It leads to the binding of signal transducer and activator of transcription 1 (STAT1) to a region spanning amino acids 319?337 of TNFR1 and induces phosphorylation of serine at 727 of STAT1. The phosphorylation of STAT1 promotes its binding to TRADD, and thus recruits Fas-associated protein with DD (FADD) and caspase 8 to form DISC complexes. This STAT1-dependent signaling results in apoptosis but not NF-?B activation. STAT1-deficiency in U3A cells counteracts tmTNF-?-induced DISC formation and apoptosis. Conversely, reconstitution of STAT1 expression restores tmTNF-?-induced apoptotic signaling in the cell line. Consistently, tmTNF-? suppresses the growth of STAT1-containing HT1080 tumors, but not of STAT1-deficient U3A tumors in vivo. Our data reveal an unappreciated molecular mechanism of tmTNF-?-induced apoptosis and may provide a new clue for cancer therapy. Twit Text FOAVip STAT1 mediates transmembrane TNF-alpha-induced formation of death-inducing signaling complex and apoptotic signaling via TNFR1 ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=28186502 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28186502 #FOAvip English Wikipedia <ref>{{Cite pmid|28186502}}</ref> STAT1 mediates transmembrane TNF-alpha-induced formation of death-inducing signaling complex and apoptotic signaling via TNFR1 #MMPMID28186502 Jiang Y; Yu M; Hu X; Han L; Yang K; Ba H; Zhang Z; Yin B; Yang XP; Li Z; Wang J Cell Death Differ 2017[Apr]; 24 (4): 660-71 PMID28186502show ga Tumor necrosis factor-alpha (TNF-?) exists in two forms: secretory TNF-? (sTNF-?) and transmembrane TNF-? (tmTNF-?). Although both forms of TNF-? induce tumor cell apoptosis, tmTNF-? is able to kill tumor cells that are resistant to sTNF-?-mediated cytotoxicity, indicating their differences in signal transduction. Here, we demonstrate that internalization of TNFR1 is crucial for sTNF-?- but not for tmTNF-?-induced apoptosis. sTNF-? induces binding of tumor necrosis factor receptor type 1-associated death domain protein (TRADD) to the death domain (DD) of TNFR1 and subsequent activation of nuclear factor kappa B (NF-?B), and the formation of death-inducing signaling complexes (DISCs) in the cytoplasm after internalization. In contrast, tmTNF-? induces DISC formation on the membrane in a DD-independent manner. It leads to the binding of signal transducer and activator of transcription 1 (STAT1) to a region spanning amino acids 319?337 of TNFR1 and induces phosphorylation of serine at 727 of STAT1. The phosphorylation of STAT1 promotes its binding to TRADD, and thus recruits Fas-associated protein with DD (FADD) and caspase 8 to form DISC complexes. This STAT1-dependent signaling results in apoptosis but not NF-?B activation. STAT1-deficiency in U3A cells counteracts tmTNF-?-induced DISC formation and apoptosis. Conversely, reconstitution of STAT1 expression restores tmTNF-?-induced apoptotic signaling in the cell line. Consistently, tmTNF-? suppresses the growth of STAT1-containing HT1080 tumors, but not of STAT1-deficient U3A tumors in vivo. Our data reveal an unappreciated molecular mechanism of tmTNF-?-induced apoptosis and may provide a new clue for cancer therapy. äSTAT1 mediates transmembrane TNF-alpha-induced formation of death-indu(epmc).pdf DeepDyve Pubget Overpricing