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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Genet
2017 ; 63
(2
): 187-193
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A conserved role of the RSC chromatin remodeler in the establishment of
nucleosome-depleted regions
#MMPMID27558480
Yague-Sanz C
; Vázquez E
; Sánchez M
; Antequera F
; Hermand D
Curr Genet
2017[May]; 63
(2
): 187-193
PMID27558480
show ga
The occupancy of nucleosomes governs access to the eukaryotic genomes and results
from a combination of biophysical features and the effect of ATP-dependent
remodelling complexes. Most promoter regions show a conserved pattern
characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal
arrays. The conserved RSC remodeler was reported to be critical to establish NDR
in vivo in budding yeast but other evidences suggested that this activity may not
be conserved in fission yeast. By reanalysing and expanding previously published
data, we propose that NDR formation requires, at least partially, RSC in both
yeast species. We also discuss the most prominent biological role of RSC and the
possibility that non-essential subunits do not define alternate versions of the
complex.