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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Korean+Med+Sci 2017 ; 32 (5): 782-8 Nephropedia Template TP
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Changes in Urinary Angiotensinogen Associated with Deterioration of Kidney Function in Patients with Type 2 Diabetes Mellitus #MMPMID28378551
Lee MJ; Kim SS; Kim IJ; Song SH; Kim EH; Seo JY; Kim JH; Kim S; Jeon YK; Kim BH; Kim YK
J Korean Med Sci 2017[May]; 32 (5): 782-8 PMID28378551show ga
Urinary angiotensinogen (AGT) is potentially a specific biomarker for the status of the intrarenal renin-angiotensin system (RAS) in patients with diabetes mellitus. We explored whether changes in urinary AGT excretion levels were associated with the deterioration of kidney function in type 2 diabetes patients with preserved kidney function. Urinary baseline AGT levels were measured in 118 type 2 diabetic patients who were not taking RAS blockers and who had estimated glomerular filtration rates (eGFRs) ? 60 mL/min/1.73 m2. A total of 91 patients were followed-up for 52 months. Changes in urinary levels of AGT (?AGT) were calculated by subtracting urinary AGT/creatinine (Cr) at baseline from urinary AGT/Cr after 1 year. ?AGT was significantly inversely correlated with annual eGFR change (? = ?0.29, P = 0.006; ? = ?0.37, P = 0.001 after adjusting for clinical factors). RAS blockers were prescribed in 36.3% of patients (n = 33) during follow-up. The ?AGT values were lower in the RAS blockers users than in the non-RAS blockers users, but the differences were not statistically significant (7.37 ± 75.88 vs. 22.55 ± 57.45 ?g/g Cr, P = 0.081). The ?AGT values remained significantly correlated with the annual rate of eGFR change (? = ?0.41, P = 0.001) in the patients who did not use RAS blockers, but no such correlation was evident in the patients who did. ?AGT is inversely correlated with annual changes in eGFR in type 2 diabetes patients with preserved kidney function, particularly in RAS blocker-naïve patients.