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10.1016/j.ymthe.2017.01.013 http://scihub22266oqcxt.onion/10.1016/j.ymthe.2017.01.013 C5383553!5383553 !28254439     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28254439 &cmd=llinks): Failed to open stream: HTTP request failed! 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The microRNA-423-3p-Bim Axis Promotes Cancer Progression and Activates Oncogenic Autophagy in Gastric Cancer |pdf=|usr=}}{{28254439 }} gab.com Text The microRNA-423-3p-Bim Axis Promotes Cancer Progression and Activates Oncogenic Autophagy in Gastric Cancer JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=28254439 #FOAvip Human serum microRNAs (miRNAs) have been shown to serve as disease fingerprints for predicting survival of cancer patients. However, the roles of specific miRNAs involved in gastric cancer (GC) are largely unknown. In this study, miRNA profiling was performed on sera obtained from six patients in good- and poor-survival groups. Expression of miR-423-3p was validated by quantitative RT-PCR in another 67 GC serum samples and paired normal and cancerous gastric tissues. Luciferase reporter assays were used to identify the target gene Bcl-2-interacting mediator of cell death (Bim). As a result, between the good-survival and poor-survival groups, the expression of nine serum miRNAs was altered more than two-fold. Among these, miR-423-3p was significantly increased in the poor-survival group, and its overexpression in GC tissues predicted poor survival in 119 patients with GC. miR-423-3p was found to promote cell proliferation, migration, and invasion in cell lines and animal models. Mechanistically, knockdown of the autophagy-related gene (Atg) 7 rescued the GC-promoting effect of miR-423-3p. In conclusion, miR-423-3p activates oncogenic and Beclin-1-dependent autophagy and promotes GC progression by reducing the expression of Bim. The newly identified miR-423-3p-Bim axis might be a potential therapeutic target in GC. Twit Text FOAVip The microRNA-423-3p-Bim Axis Promotes Cancer Progression and Activates Oncogenic Autophagy in Gastric Cancer ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=28254439 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28254439 #FOAvip English Wikipedia <ref>{{Cite pmid|28254439 }}</ref> The microRNA-423-3p-Bim Axis Promotes Cancer Progression and Activates Oncogenic Autophagy in Gastric Cancer #MMPMID28254439 Kong P ; Zhu X ; Geng Q ; Xia L ; Sun X ; Chen Y ; Li W ; Zhou Z ; Zhan Y ; Xu D Mol Ther 2017[Apr]; 25 (4 ): 1027-1037 PMID28254439 show ga Human serum microRNAs (miRNAs) have been shown to serve as disease fingerprints for predicting survival of cancer patients. However, the roles of specific miRNAs involved in gastric cancer (GC) are largely unknown. In this study, miRNA profiling was performed on sera obtained from six patients in good- and poor-survival groups. Expression of miR-423-3p was validated by quantitative RT-PCR in another 67 GC serum samples and paired normal and cancerous gastric tissues. Luciferase reporter assays were used to identify the target gene Bcl-2-interacting mediator of cell death (Bim). As a result, between the good-survival and poor-survival groups, the expression of nine serum miRNAs was altered more than two-fold. Among these, miR-423-3p was significantly increased in the poor-survival group, and its overexpression in GC tissues predicted poor survival in 119 patients with GC. miR-423-3p was found to promote cell proliferation, migration, and invasion in cell lines and animal models. Mechanistically, knockdown of the autophagy-related gene (Atg) 7 rescued the GC-promoting effect of miR-423-3p. In conclusion, miR-423-3p activates oncogenic and Beclin-1-dependent autophagy and promotes GC progression by reducing the expression of Bim. The newly identified miR-423-3p-Bim axis might be a potential therapeutic target in GC. |*Gene Expression Regulation, Neoplastic [MESH] |*RNA Interference [MESH] |Animals [MESH] |Autophagy/*genetics [MESH] |Bcl-2-Like Protein 11/*genetics [MESH] |Beclin-1/genetics [MESH] |Cell Line, Tumor [MESH] |Cell Movement/genetics [MESH] |Cell Proliferation/genetics [MESH] |Disease Models, Animal [MESH] |Disease Progression [MESH] |Gene Expression Profiling [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Mice [MESH] |MicroRNAs/blood/*genetics [MESH] |Prognosis [MESH] |Stomach Neoplasms/*genetics/mortality/*pathology [MESH] |Tumor Burden [MESH]The microRNA-423-3p-Bim Axis Promotes Cancer Progression and Activates(epmc).pdf DeepDyve Pubget Overpricing