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10.1038/nsmb.3389 http://scihub22266oqcxt.onion/10.1038/nsmb.3389 C5383508!5383508 !28287632     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28287632 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Struct+Mol+Biol 2017 ; 24 (4 ): 419-430 Nephropedia Template TP {{tp|p=28287632 |t=2017. A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function |pdf=|usr=}}{{28287632 }} gab.com Text A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function JO: Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=28287632 #FOAvip In the nervous system, rapidly occurring processes such as neuronal transmission and calcium signaling are affected by short-term inhibition of proteasome function. It is unclear how proteasomes are able to acutely regulate such processes, as this action is inconsistent with their canonical role in proteostasis. Here we describe a mammalian nervous-system-specific membrane proteasome complex that directly and rapidly modulates neuronal function by degrading intracellular proteins into extracellular peptides that can stimulate neuronal signaling. This proteasome complex is closely associated with neuronal plasma membranes, exposed to the extracellular space, and catalytically active. Selective inhibition of the membrane proteasome complex by a cell-impermeable proteasome inhibitor blocked the production of extracellular peptides and attenuated neuronal-activity-induced calcium signaling. Moreover, we observed that membrane-proteasome-derived peptides were sufficient to induce neuronal calcium signaling. Our discoveries challenge the prevailing notion that proteasomes function primarily to maintain proteostasis, and highlight a form of neuronal communication that takes place through a membrane proteasome complex. Twit Text FOAVip A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function ????Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=28287632 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28287632 #FOAvip English Wikipedia <ref>{{Cite pmid|28287632 }}</ref> A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function #MMPMID28287632 Ramachandran KV ; Margolis SS Nat Struct Mol Biol 2017[Apr]; 24 (4 ): 419-430 PMID28287632 show ga In the nervous system, rapidly occurring processes such as neuronal transmission and calcium signaling are affected by short-term inhibition of proteasome function. It is unclear how proteasomes are able to acutely regulate such processes, as this action is inconsistent with their canonical role in proteostasis. Here we describe a mammalian nervous-system-specific membrane proteasome complex that directly and rapidly modulates neuronal function by degrading intracellular proteins into extracellular peptides that can stimulate neuronal signaling. This proteasome complex is closely associated with neuronal plasma membranes, exposed to the extracellular space, and catalytically active. Selective inhibition of the membrane proteasome complex by a cell-impermeable proteasome inhibitor blocked the production of extracellular peptides and attenuated neuronal-activity-induced calcium signaling. Moreover, we observed that membrane-proteasome-derived peptides were sufficient to induce neuronal calcium signaling. Our discoveries challenge the prevailing notion that proteasomes function primarily to maintain proteostasis, and highlight a form of neuronal communication that takes place through a membrane proteasome complex. |Animals [MESH] |Cell Membrane/*metabolism [MESH] |Cerebral Cortex/cytology [MESH] |Cytoplasm/metabolism [MESH] |Extracellular Space/metabolism [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Immunoblotting [MESH] |Mammals/*metabolism [MESH] |Membrane Glycoproteins/metabolism [MESH] |Mice, Inbred C57BL [MESH] |Models, Biological [MESH] |Nerve Tissue Proteins/metabolism [MESH] |Nervous System/*metabolism [MESH] |Neurons/*metabolism/ultrastructure [MESH] |Oligopeptides/metabolism [MESH] |Peptides/metabolism [MESH] |Proteasome Endopeptidase Complex/*metabolism [MESH] |Protein Subunits/metabolism [MESH] |Proteolysis [MESH]A mammalian nervous-system-specific plasma membrane proteasome complex(epmc).pdf DeepDyve Pubget Overpricing