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10.1038/nature21693 http://scihub22266oqcxt.onion/10.1038/nature21693 C5383507!5383507!28355185     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28355185&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2017 ; 544 (7648): 53-8 Nephropedia Template TP {{tp|p=28355185|t=2017. Myeloid progenitor cluster formation drives emergency and leukemic myelopoiesis |pdf=|usr=}}{{28355185}} gab.com Text Myeloid progenitor cluster formation drives emergency and leukemic myelopoiesis JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=28355185 #FOAvip While many aspects of blood production are now well understood, the spatial organization of myeloid differentiation in the bone marrow (BM) remains unknown. Here, we use imaging to track granulocyte/macrophage progenitor (GMP) behavior during emergency and leukemic myelopoiesis. At steady state, we find individual GMPs scattered throughout the BM. During regeneration, we observe expanding GMP patches forming defined GMP clusters, which, in turn, locally differentiate into granulocytes. We describe how the timed release of important BM niche signals (SCF, IL-1?, G-CSF, TGF-?, CXCL4) and activation of an inducible Irf8/?-catenin progenitor self-renewal network controls the transient formation of regenerating GMP clusters. In leukemia, we show that GMP clusters are constantly produced due to persistent activation of the self-renewal network and lack of termination cytokines that normally restore stem cell quiescence. Our results uncover a previously unrecognized dynamic behavior of GMPs in situ, which tunes emergency myelopoiesis and is hijacked in leukemia. Twit Text FOAVip Myeloid progenitor cluster formation drives emergency and leukemic myelopoiesis ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=28355185 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28355185 #FOAvip English Wikipedia <ref>{{Cite pmid|28355185}}</ref> Myeloid progenitor cluster formation drives emergency and leukemic myelopoiesis #MMPMID28355185 Hérault A; Binnewies M; Leong S; Calero-Nieto FJ; Zhang SY; Kang YA; Wang X; Pietras EM; Chu SH; Barry-Holson K; Armstrong S; Göttgens B; Passegué E Nature 2017[Apr]; 544 (7648): 53-8 PMID28355185show ga While many aspects of blood production are now well understood, the spatial organization of myeloid differentiation in the bone marrow (BM) remains unknown. Here, we use imaging to track granulocyte/macrophage progenitor (GMP) behavior during emergency and leukemic myelopoiesis. At steady state, we find individual GMPs scattered throughout the BM. During regeneration, we observe expanding GMP patches forming defined GMP clusters, which, in turn, locally differentiate into granulocytes. We describe how the timed release of important BM niche signals (SCF, IL-1?, G-CSF, TGF-?, CXCL4) and activation of an inducible Irf8/?-catenin progenitor self-renewal network controls the transient formation of regenerating GMP clusters. In leukemia, we show that GMP clusters are constantly produced due to persistent activation of the self-renewal network and lack of termination cytokines that normally restore stem cell quiescence. Our results uncover a previously unrecognized dynamic behavior of GMPs in situ, which tunes emergency myelopoiesis and is hijacked in leukemia. äMyeloid progenitor cluster formation drives emergency and leukemic mye(epmc).pdf DeepDyve Pubget Overpricing