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Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Exp+Immunol 2017 ; 188 (2): 299-310 Nephropedia Template TP
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Lymph node and circulating T cell characteristics are strongly correlated in end?stage renal disease patients, but highly differentiated T cells reside within the circulation #MMPMID28142201
Dedeoglu B; de Weerd AE; Huang L; Langerak AW; Dor FJ; Klepper M; Verschoor W; Reijerkerk D; Baan CC; Litjens NHR; Betjes MGH
Clin Exp Immunol 2017[May]; 188 (2): 299-310 PMID28142201show ga
Ageing is associated with changes in the peripheral T cell immune system, which can be influenced significantly by latent cytomegalovirus (CMV) infection. To what extent changes in circulating T cell populations correlate with T cell composition of the lymph node (LN) is unclear, but is crucial for a comprehensive understanding of the T cell system. T cells from peripheral blood (PB) and LN of end?stage renal disease patients were analysed for frequency of recent thymic emigrants using CD31 expression and T cell receptor excision circle content, relative telomere length and expression of differentiation markers. Compared with PB, LN contained relatively more CD4+ than CD8+ T cells (P?0·001). The percentage of naive and central memory CD4+ and CD8+ T cells and thymic output parameters showed a strong linear correlation between PB and LN. Highly differentiated CD28null T cells, being CD27?, CD57+ or programmed death 1 (PD?1+), were found almost exclusively in the circulation but not in LN. An age?related decline in naive CD4+ and CD8+ T cell frequency was observed (P?=?0·035 and P?=?0·002, respectively) within LN, concomitant with an increase in central memory CD8+ T cells (P?=?0·033). Latent CMV infection increased dramatically the frequency of circulating terminally differentiated T cells, but did not alter T cell composition and ageing parameters of LN significantly. Overall T cell composition and measures of thymic function in PB and LN are correlated strongly. However, highly differentiated CD28null T cells, which may comprise a large part of circulating T cells in CMV?seropositive individuals, are found almost exclusively within the circulation.