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10.1111/cei.12934 http://scihub22266oqcxt.onion/10.1111/cei.12934 C5383449!5383449 !28142201     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28142201 &cmd=llinks): Failed to open stream: HTTP request failed! 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Lymph node and circulating T cell characteristics are strongly correlated in end-stage renal disease patients, but highly differentiated T cells reside within the circulation |pdf=|usr=}}{{28142201 }} gab.com Text Lymph node and circulating T cell characteristics are strongly correlated in end-stage renal disease patients, but highly differentiated T cells reside within the circulation JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28142201 #FOAvip Ageing is associated with changes in the peripheral T cell immune system, which can be influenced significantly by latent cytomegalovirus (CMV) infection. To what extent changes in circulating T cell populations correlate with T cell composition of the lymph node (LN) is unclear, but is crucial for a comprehensive understanding of the T cell system. T cells from peripheral blood (PB) and LN of end-stage renal disease patients were analysed for frequency of recent thymic emigrants using CD31 expression and T cell receptor excision circle content, relative telomere length and expression of differentiation markers. Compared with PB, LN contained relatively more CD4(+) than CD8(+) T cells (P?<?0·001). The percentage of naive and central memory CD4(+) and CD8(+) T cells and thymic output parameters showed a strong linear correlation between PB and LN. Highly differentiated CD28(null) T cells, being CD27(-) , CD57(+) or programmed death 1 (PD-1(+) ), were found almost exclusively in the circulation but not in LN. An age-related decline in naive CD4(+) and CD8(+) T cell frequency was observed (P?=?0·035 and P?=?0·002, respectively) within LN, concomitant with an increase in central memory CD8(+) T cells (P?=?0·033). Latent CMV infection increased dramatically the frequency of circulating terminally differentiated T cells, but did not alter T cell composition and ageing parameters of LN significantly. Overall T cell composition and measures of thymic function in PB and LN are correlated strongly. However, highly differentiated CD28(null) T cells, which may comprise a large part of circulating T cells in CMV-seropositive individuals, are found almost exclusively within the circulation. Twit Text FOAVip Lymph node and circulating T cell characteristics are strongly correlated in end-stage renal disease patients, but highly differentiated T cells reside within the circulation ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28142201 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28142201 #FOAvip English Wikipedia <ref>{{Cite pmid|28142201 }}</ref> Lymph node and circulating T cell characteristics are strongly correlated in end-stage renal disease patients, but highly differentiated T cells reside within the circulation #MMPMID28142201 Dedeoglu B ; de Weerd AE ; Huang L ; Langerak AW ; Dor FJ ; Klepper M ; Verschoor W ; Reijerkerk D ; Baan CC ; Litjens NH ; Betjes MG Clin Exp Immunol 2017[May]; 188 (2 ): 299-310 PMID28142201 show ga Ageing is associated with changes in the peripheral T cell immune system, which can be influenced significantly by latent cytomegalovirus (CMV) infection. To what extent changes in circulating T cell populations correlate with T cell composition of the lymph node (LN) is unclear, but is crucial for a comprehensive understanding of the T cell system. T cells from peripheral blood (PB) and LN of end-stage renal disease patients were analysed for frequency of recent thymic emigrants using CD31 expression and T cell receptor excision circle content, relative telomere length and expression of differentiation markers. Compared with PB, LN contained relatively more CD4(+) than CD8(+) T cells (P? |Aged [MESH] |Aging/immunology [MESH] |Antigens, Differentiation, T-Lymphocyte/analysis [MESH] |CD4-Positive T-Lymphocytes/*immunology/metabolism [MESH] |CD8-Positive T-Lymphocytes/*immunology/metabolism [MESH] |Cell Differentiation [MESH] |Cytomegalovirus Infections/immunology [MESH] |Female [MESH] |Humans [MESH] |Immunologic Memory [MESH] |Kidney Failure, Chronic/*immunology [MESH] |Lymph Nodes/cytology/*immunology [MESH] |Lymphocyte Activation [MESH] |Lymphocyte Count [MESH] |Male [MESH] |Middle Aged [MESH] |Platelet Endothelial Cell Adhesion Molecule-1/genetics [MESH]Lymph node and circulating T cell characteristics are strongly correla(epmc).pdf DeepDyve Pubget Overpricing