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10.1111/cei.12930 http://scihub22266oqcxt.onion/10.1111/cei.12930 C5383437!5383437 !28120479     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28120479 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Exp+Immunol 2017 ; 188 (2 ): 254-262 Nephropedia Template TP {{tp|p=28120479 |t=2017. Urinary haptoglobin, alpha-1 anti-chymotrypsin and retinol binding protein identified by proteomics as potential biomarkers for lupus nephritis |pdf=|usr=}}{{28120479 }} gab.com Text Urinary haptoglobin, alpha-1 anti-chymotrypsin and retinol binding protein identified by proteomics as potential biomarkers for lupus nephritis JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28120479 #FOAvip The study was aimed at identification by proteomics and validation by enzyme-linked immunosorbent assay (ELISA) of potential urinary biomarkers for lupus nephritis. Study subjects comprised 88 systemic lupus erythematosus (SLE) patients and 60 controls (rheumatoid arthritis, diabetes mellitus and healthy individuals). Based on the SLE disease activity index (SLEDAI), patients were classified as active renal (AR), active non-renal (ANR) or inactive disease (ID). Urinary proteins from a group of patients with AR or ID were resolved by two-dimensional gel electrophoresis and identified by matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS/MS). The selected biomarkers were validated by ELISA using samples from all patients and controls. AR patients were followed-up for 12 months after start of therapy. Three urinary proteins, alpha-1 anti-chymotrypsin (ACT), haptoglobin (HAP) and retinol binding protein (RBP), were detected in patients with AR and not ID. Upon validation, ACT levels were higher in AR patients than the other groups (P?<?0·001) and showed good correlation with renal SLEDAI (r?=?0·577, P?<?0·001) as well as SLEDAI (r?=?0·461, P?<?0·001). Similarly, HAP levels were > 10-fold higher in AR than other groups (P?<?0·001) and correlated well with renal SLEDAI (r?=?0·594, P?<?0·001) and SLEDAI (r?=?0·371, P?<?0·01). RBP levels were also higher in AR patients than in other groups (P?<?0·05), except diabetes, and showed moderate correlation with renal SLEDAI (r?=?0·284, P?<?0·008) and SLEDAI (r?=?0·316, P?<?0·003). Upon follow-up with treatment, levels of all three proteins declined at 6 and 12 months (P?<?0·01). Multiple logistic regression identified ACT as the best marker to differentiate AR from ANR. Urinary HAP, ACT and RBP are potential biomarkers for lupus nephritis activity. Twit Text FOAVip Urinary haptoglobin, alpha-1 anti-chymotrypsin and retinol binding protein identified by proteomics as potential biomarkers for lupus nephritis ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28120479 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28120479 #FOAvip English Wikipedia <ref>{{Cite pmid|28120479 }}</ref> Urinary haptoglobin, alpha-1 anti-chymotrypsin and retinol binding protein identified by proteomics as potential biomarkers for lupus nephritis #MMPMID28120479 Aggarwal A ; Gupta R ; Negi VS ; Rajasekhar L ; Misra R ; Singh P ; Chaturvedi V ; Sinha S Clin Exp Immunol 2017[May]; 188 (2 ): 254-262 PMID28120479 show ga The study was aimed at identification by proteomics and validation by enzyme-linked immunosorbent assay (ELISA) of potential urinary biomarkers for lupus nephritis. Study subjects comprised 88 systemic lupus erythematosus (SLE) patients and 60 controls (rheumatoid arthritis, diabetes mellitus and healthy individuals). Based on the SLE disease activity index (SLEDAI), patients were classified as active renal (AR), active non-renal (ANR) or inactive disease (ID). Urinary proteins from a group of patients with AR or ID were resolved by two-dimensional gel electrophoresis and identified by matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS/MS). The selected biomarkers were validated by ELISA using samples from all patients and controls. AR patients were followed-up for 12 months after start of therapy. Three urinary proteins, alpha-1 anti-chymotrypsin (ACT), haptoglobin (HAP) and retinol binding protein (RBP), were detected in patients with AR and not ID. Upon validation, ACT levels were higher in AR patients than the other groups (P? 10-fold higher in AR than other groups (P? |Adult [MESH] |Arthritis, Rheumatoid/urine [MESH] |Biomarkers/urine [MESH] |Diabetes Mellitus/urine [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Female [MESH] |Haptoglobins/*urine [MESH] |Humans [MESH] |Logistic Models [MESH] |Lupus Erythematosus, Systemic/urine [MESH] |Lupus Nephritis/*diagnosis/drug therapy/urine [MESH] |Male [MESH] |Proteomics/methods [MESH] |Retinol-Binding Proteins/*urine [MESH] |Severity of Illness Index [MESH] |Tandem Mass Spectrometry [MESH] |Young Adult [MESH]Urinary haptoglobin, alpha-1 anti-chymotrypsin and retinol binding pro(epmc).pdf DeepDyve Pubget Overpricing