Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/cei.12937 http://scihub22266oqcxt.onion/10.1111/cei.12937 C5383436!5383436!28152566     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28152566&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2017 ; 188 (2): 195-207 Nephropedia Template TP {{tp|p=28152566|t=2017. Exacerbation of spontaneous autoimmune nephritis following regulatory T cell depletion in B cell lymphoma 2?interacting mediator knock?out mice |pdf=|usr=}}{{28152566}} gab.com Text Exacerbation of spontaneous autoimmune nephritis following regulatory T cell depletion in B cell lymphoma 2 interacting mediator knock out mice JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28152566 #FOAvip Regulatory T cells (Tregs) have been recognized as central mediators for maintaining peripheral tolerance and limiting autoimmune diseases. The loss of Tregs or their function has been associated with exacerbation of autoimmune disease. However, the temporary loss of Tregs in the chronic spontaneous disease model has not been investigated. In this study, we evaluated the role of Tregs in a novel chronic spontaneous glomerulonephritis model of B cell lymphoma 2?interacting mediator (Bim) knock?out mice by transient depleting Tregs. Bim is a pro?apoptotic member of the B cell lymphoma 2 (Bcl?2) family. Bim knock?out (Bim?/?) mice fail to delete autoreactive T cells in thymus, leading to chronic spontaneous autoimmune kidney disease. We found that Treg depletion in Bim?/? mice exacerbated the kidney injury with increased proteinuria, impaired kidney function, weight loss and greater histological injury compared with wild?type mice. There was a significant increase in interstitial infiltrate of inflammatory cells, antibody deposition and tubular damage. Furthermore, the serum levels of cytokines interleukin (IL)?2, IL?4, IL?6, IL?10, IL?17?, interferon (IFN)?? and tumour necrosis factor (TNF)?? were increased significantly after Treg depletion in Bim?/? mice. This study demonstrates that transient depletion of Tregs leads to enhanced self?reactive T effector cell function followed by exacerbation of kidney disease in the chronic spontaneous kidney disease model of Bim?deficient mice. Twit Text FOAVip Exacerbation of spontaneous autoimmune nephritis following regulatory T cell depletion in B cell lymphoma 2 interacting mediator knock out mice ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28152566 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28152566 #FOAvip English Wikipedia <ref>{{Cite pmid|28152566}}</ref> Exacerbation of spontaneous autoimmune nephritis following regulatory T cell depletion in B cell lymphoma 2?interacting mediator knock?out mice #MMPMID28152566 Wang YM; Zhang GY; Wang Y; Hu M; Zhou JJ; Sawyer A; Cao Q; Wang Y; Zheng G; Lee VWS; Harris DCH; Alexander SI Clin Exp Immunol 2017[May]; 188 (2): 195-207 PMID28152566show ga Regulatory T cells (Tregs) have been recognized as central mediators for maintaining peripheral tolerance and limiting autoimmune diseases. The loss of Tregs or their function has been associated with exacerbation of autoimmune disease. However, the temporary loss of Tregs in the chronic spontaneous disease model has not been investigated. In this study, we evaluated the role of Tregs in a novel chronic spontaneous glomerulonephritis model of B cell lymphoma 2?interacting mediator (Bim) knock?out mice by transient depleting Tregs. Bim is a pro?apoptotic member of the B cell lymphoma 2 (Bcl?2) family. Bim knock?out (Bim?/?) mice fail to delete autoreactive T cells in thymus, leading to chronic spontaneous autoimmune kidney disease. We found that Treg depletion in Bim?/? mice exacerbated the kidney injury with increased proteinuria, impaired kidney function, weight loss and greater histological injury compared with wild?type mice. There was a significant increase in interstitial infiltrate of inflammatory cells, antibody deposition and tubular damage. Furthermore, the serum levels of cytokines interleukin (IL)?2, IL?4, IL?6, IL?10, IL?17?, interferon (IFN)?? and tumour necrosis factor (TNF)?? were increased significantly after Treg depletion in Bim?/? mice. This study demonstrates that transient depletion of Tregs leads to enhanced self?reactive T effector cell function followed by exacerbation of kidney disease in the chronic spontaneous kidney disease model of Bim?deficient mice. äExacerbation of spontaneous autoimmune nephritis following regulatory (epmc).pdf DeepDyve Pubget Overpricing