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10.7554/eLife.24695 http://scihub22266oqcxt.onion/10.7554/eLife.24695 C5383398!5383398!28384097     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28384097|t=2017. Domestic chickens activate a piRNA defense against avian leukosis virus |pdf=|usr=}}{{28384097}} gab.com Text Domestic chickens activate a piRNA defense against avian leukosis virus JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28384097 #FOAvip PIWI-interacting RNAs (piRNAs) protect the germ line by targeting transposable elements (TEs) through the base-pair complementarity. We do not know how piRNAs co-evolve with TEs in chickens. Here we reported that all active TEs in the chicken germ line are targeted by piRNAs, and as TEs lose their activity, the corresponding piRNAs erode away. We observed de novo piRNA birth as host responds to a recent retroviral invasion. Avian leukosis virus (ALV) has endogenized prior to chicken domestication, remains infectious, and threatens poultry industry. Domestic fowl produce piRNAs targeting ALV from one ALV provirus that was known to render its host ALV resistant. This proviral locus does not produce piRNAs in undomesticated wild chickens. Our findings uncover rapid piRNA evolution reflecting contemporary TE activity, identify a new piRNA acquisition modality by activating a pre-existing genomic locus, and extend piRNA defense roles to include the period when endogenous retroviruses are still infectious.DOI:http://dx.doi.org/10.7554/eLife.24695.001 Twit Text FOAVip Domestic chickens activate a piRNA defense against avian leukosis virus ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28384097 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28384097 #FOAvip English Wikipedia <ref>{{Cite pmid|28384097}}</ref> Domestic chickens activate a piRNA defense against avian leukosis virus #MMPMID28384097 Sun YH; Xie LH; Zhuo X; Chen Q; Ghoneim D; Zhang B; Jagne J; Yang C; Li XZ eLife 2017[]; 6 (ä): ä PMID28384097show ga PIWI-interacting RNAs (piRNAs) protect the germ line by targeting transposable elements (TEs) through the base-pair complementarity. We do not know how piRNAs co-evolve with TEs in chickens. Here we reported that all active TEs in the chicken germ line are targeted by piRNAs, and as TEs lose their activity, the corresponding piRNAs erode away. We observed de novo piRNA birth as host responds to a recent retroviral invasion. Avian leukosis virus (ALV) has endogenized prior to chicken domestication, remains infectious, and threatens poultry industry. Domestic fowl produce piRNAs targeting ALV from one ALV provirus that was known to render its host ALV resistant. This proviral locus does not produce piRNAs in undomesticated wild chickens. Our findings uncover rapid piRNA evolution reflecting contemporary TE activity, identify a new piRNA acquisition modality by activating a pre-existing genomic locus, and extend piRNA defense roles to include the period when endogenous retroviruses are still infectious.DOI:http://dx.doi.org/10.7554/eLife.24695.001 äDomestic chickens activate a piRNA defense against avian leukosis viru(epmc).pdf DeepDyve Pubget Overpricing