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10.1371/journal.pone.0175335 http://scihub22266oqcxt.onion/10.1371/journal.pone.0175335 C5383287!5383287 !28384267     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28384267 &cmd=llinks): Failed to open stream: HTTP request failed! 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Association between different anticholinergic drugs and subsequent dementia risk in patients with diabetes mellitus |pdf=|usr=}}{{28384267 }} gab.com Text Association between different anticholinergic drugs and subsequent dementia risk in patients with diabetes mellitus JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28384267 #FOAvip BACKGROUND: The effects of oxybutynin, solifenacin and tolterodine on dementia risk in patients with diabetes mellitus (DM) remain unknown. We investigated the effects of oxybutynin, solifenacin and tolterodine on dementia risk in patients with DM. METHODS: We conducted a cohort study by using the diabetes dataset of the Taiwan National Health Insurance Research Database from 1 January, 2002 to 31 December, 2013. We included 10,938 patients received one type of oxybutynin, solifenacin, or tolterodine, while 564,733 had not. We included a comparable number of patients not receiving oxybutynin, solifenacin, or tolterodine as controls through systematic random sampling matching by age, gender, and the year of the index date with 1 to 1 ratio. The dementia risk was estimated through multivariate Cox proportional hazard regression after adjustment for several confounding factors. RESULTS: The dementia event rates were 3.9% in the oxybutynin group, 4.3% in the solifenacin group, 2.2% in the tolterodine group and 1.2% in the control group (P<0.001). The adjusted HRs compared to nonusers of anticholinergic drugs were 2.35 (95% CI, 1.96 to 2.81), 2.16 (95% CI, 1.81 to 2.58), and 2.24 (95% CI, 1.85 to 2.73), respectively, for patients receiving oxybutynin, solifenacin, or tolterodine. CONCLUSION: Our study indicates an association between taking oxybutynin, solifenacin and tolterodine and the subsequent diagnosis of dementia in DM patients. Moreover, the patients using oxybutynin had highest risk. The impact of these three drugs on risk of dementia in non-diabetic populations is warrant. Twit Text FOAVip Association between different anticholinergic drugs and subsequent dementia risk in patients with diabetes mellitus ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28384267 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28384267 #FOAvip English Wikipedia <ref>{{Cite pmid|28384267 }}</ref> Association between different anticholinergic drugs and subsequent dementia risk in patients with diabetes mellitus #MMPMID28384267 Yang YW ; Liu HH ; Lin TH ; Chuang HY ; Hsieh T PLoS One 2017[]; 12 (4 ): e0175335 PMID28384267 show ga BACKGROUND: The effects of oxybutynin, solifenacin and tolterodine on dementia risk in patients with diabetes mellitus (DM) remain unknown. We investigated the effects of oxybutynin, solifenacin and tolterodine on dementia risk in patients with DM. METHODS: We conducted a cohort study by using the diabetes dataset of the Taiwan National Health Insurance Research Database from 1 January, 2002 to 31 December, 2013. We included 10,938 patients received one type of oxybutynin, solifenacin, or tolterodine, while 564,733 had not. We included a comparable number of patients not receiving oxybutynin, solifenacin, or tolterodine as controls through systematic random sampling matching by age, gender, and the year of the index date with 1 to 1 ratio. The dementia risk was estimated through multivariate Cox proportional hazard regression after adjustment for several confounding factors. RESULTS: The dementia event rates were 3.9% in the oxybutynin group, 4.3% in the solifenacin group, 2.2% in the tolterodine group and 1.2% in the control group (P<0.001). The adjusted HRs compared to nonusers of anticholinergic drugs were 2.35 (95% CI, 1.96 to 2.81), 2.16 (95% CI, 1.81 to 2.58), and 2.24 (95% CI, 1.85 to 2.73), respectively, for patients receiving oxybutynin, solifenacin, or tolterodine. CONCLUSION: Our study indicates an association between taking oxybutynin, solifenacin and tolterodine and the subsequent diagnosis of dementia in DM patients. Moreover, the patients using oxybutynin had highest risk. The impact of these three drugs on risk of dementia in non-diabetic populations is warrant. |*Diabetes Complications [MESH] |Aged [MESH] |Cholinergic Antagonists/adverse effects/*therapeutic use [MESH] |Cohort Studies [MESH] |Dementia/*chemically induced/complications [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH]Association between different anticholinergic drugs and subsequent dem(epmc).pdf DeepDyve Pubget Overpricing