Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.cellimm.2017.02.002 http://scihub22266oqcxt.onion/10.1016/j.cellimm.2017.02.002 C5383205!5383205!28238361     free     free     free       Cell+Immunol 2017 ; 314 (ä): 54-62 Nephropedia Template TP {{tp|p=28238361|t=2017. Macrophage regulation of B cell proliferation |pdf=|usr=}}{{28238361}} gab.com Text Macrophage regulation of B cell proliferation JO: Cell Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28238361 #FOAvip Unlike organized lymphoid tissue, the tumor microenvironment (TME) often includes a high proportion of immunosuppressive macrophages. We model the TME by culturing peritoneal cavity (PerC) cells that naturally have a high macrophage to lymphocyte ratio. Prior studies revealed that, following TCR ligation, PerC T cell proliferation is suppressed due to IFN?-triggered inducible nitric oxide synthase expression. In this study we assessed the ability of PerC B cells to respond to surrogate activating signals in the presence of high numbers of macrophages. Surface IgM (BCR) ligation led to cyclooxygenase-mediated, and TLR-4 ligation to IL10-mediated, suppression of PerC B cell proliferation. In contrast, PerC B cells had a robust response to CD40 ligation, which could overcome the suppression generated by the BCR or TLR-4 response. However, the CD40 response was suppressed by concurrent TCR ligation. These results reveal the challenges of promoting B and T cell responses in macrophage-rich conditions that model the TME. Twit Text FOAVip Macrophage regulation of B cell proliferation ????Cell Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28238361 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28238361 #FOAvip English Wikipedia <ref>{{Cite pmid|28238361}}</ref> Macrophage regulation of B cell proliferation #MMPMID28238361 Goldman N; Valiuskyte K; Londregan J; Swider A; Somerville J; Riggs JE Cell Immunol 2017[Apr]; 314 (ä): 54-62 PMID28238361show ga Unlike organized lymphoid tissue, the tumor microenvironment (TME) often includes a high proportion of immunosuppressive macrophages. We model the TME by culturing peritoneal cavity (PerC) cells that naturally have a high macrophage to lymphocyte ratio. Prior studies revealed that, following TCR ligation, PerC T cell proliferation is suppressed due to IFN?-triggered inducible nitric oxide synthase expression. In this study we assessed the ability of PerC B cells to respond to surrogate activating signals in the presence of high numbers of macrophages. Surface IgM (BCR) ligation led to cyclooxygenase-mediated, and TLR-4 ligation to IL10-mediated, suppression of PerC B cell proliferation. In contrast, PerC B cells had a robust response to CD40 ligation, which could overcome the suppression generated by the BCR or TLR-4 response. However, the CD40 response was suppressed by concurrent TCR ligation. These results reveal the challenges of promoting B and T cell responses in macrophage-rich conditions that model the TME. äMacrophage regulation of B cell proliferation (epmc).pdf DeepDyve Pubget Overpricing