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2017 ; 27
(1
): 153-176
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The role of laboratory testing in detection and classification of chronic kidney
disease: national recommendations
#MMPMID28392738
Biljak VR
; Honovi? L
; Matica J
; Kre?i? B
; Vojak S?
Biochem Med (Zagreb)
2017[Feb]; 27
(1
): 153-176
PMID28392738
show ga
Chronic kidney disease (CKD) is a common clinical condition with significant
adverse consequences for the patient and it is recognized as a significant public
health problem. The role of laboratory medicine in diagnosis and management of
CKD is of great importance: the diagnosis and staging are based on estimation of
glomerular filtration rate (eGFR) and assessment of albuminuria (or proteinuria).
Therefore, the joint working group of the Croatian society of medical
biochemistry and laboratory medicine and Croatian chamber of medical biochemists
for laboratory diagnostics in CKD issued this national recommendation regarding
laboratory diagnostics of CKD.?Key factors for laboratories implementing the
national guidelines for the diagnosis and management of CKD are:?1. Ensure good
communication between laboratory professionals and clinicians, such as
nephrologists or specialists in general/family medicine,?2. Ensure all patients
are provided with the same availability of laboratory diagnostics,?3. Ensure
creatinine assays are traceable to isotope dilution mass spectrometry (IDMS)
method and have minimal bias and acceptable imprecision,?4. Select the
appropriate GFR estimating formula. Recommended equation is the 2009 Chronic
Kidney Disease Epidemiology Collaboration (CKD - EPI) equation,?5. In reporting
the key laboratory tests (creatinine, eGFR, urine albumin-to-creatinine ratio,
urine protein-to-creatinine ratio) use the appropriate reporting units,?6.
Provide adequate information on limitations of creatinine measurement.?The
manuscript has been organized to identify critical points in laboratory tests
used in basic laboratory diagnostics of CKD and is based on the Kidney Disease:
Improving Global Outcomes (KDIGO) 2012 Clinical Practice Guideline for the
Evaluation and Management of Chronic Kidney Disease.
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