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10.1038/emm.2017.42 http://scihub22266oqcxt.onion/10.1038/emm.2017.42 C5382566!5382566 !28360428     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28360428 &cmd=llinks): Failed to open stream: HTTP request failed! 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Molecular checkpoints controlling natural killer cell activation and their modulation for cancer immunotherapy |pdf=|usr=}}{{28360428 }} gab.com Text Molecular checkpoints controlling natural killer cell activation and their modulation for cancer immunotherapy JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28360428 #FOAvip Natural killer (NK) cells have gained considerable attention as promising therapeutic tools for cancer therapy due to their innate selectivity against cancer cells over normal healthy cells. With an array of receptors evolved to sense cellular alterations, NK cells provide early protection against cancer cells by producing cytokines and chemokines and exerting direct cytolytic activity. These effector functions are governed by signals transmitted through multiple receptor-ligand interactions but are not achieved by engaging a single activating receptor on resting NK cells. Rather, they require the co-engagement of different activating receptors that use distinct signaling modules, due to a cell-intrinsic inhibition mechanism. The redundancy of synergizing receptors and the inhibition of NK cell function by a single class of inhibitory receptor suggest the presence of common checkpoints to control NK cell activation through different receptors. These molecular checkpoints would be therapeutically targeted to harness the power of NK cells against diverse cancer cells that express heterogeneous ligands for NK cell receptors. Recent advances in understanding the activation of NK cells have revealed promising candidates in this category. Targeting such molecular checkpoints will facilitate NK cell activation by lowering activation thresholds, thereby providing therapeutic strategies that optimize NK cell reactivity against cancer. Twit Text FOAVip Molecular checkpoints controlling natural killer cell activation and their modulation for cancer immunotherapy ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28360428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28360428 #FOAvip English Wikipedia <ref>{{Cite pmid|28360428 }}</ref> Molecular checkpoints controlling natural killer cell activation and their modulation for cancer immunotherapy #MMPMID28360428 Kwon HJ ; Kim N ; Kim HS Exp Mol Med 2017[Mar]; 49 (3 ): e311 PMID28360428 show ga Natural killer (NK) cells have gained considerable attention as promising therapeutic tools for cancer therapy due to their innate selectivity against cancer cells over normal healthy cells. With an array of receptors evolved to sense cellular alterations, NK cells provide early protection against cancer cells by producing cytokines and chemokines and exerting direct cytolytic activity. These effector functions are governed by signals transmitted through multiple receptor-ligand interactions but are not achieved by engaging a single activating receptor on resting NK cells. Rather, they require the co-engagement of different activating receptors that use distinct signaling modules, due to a cell-intrinsic inhibition mechanism. The redundancy of synergizing receptors and the inhibition of NK cell function by a single class of inhibitory receptor suggest the presence of common checkpoints to control NK cell activation through different receptors. These molecular checkpoints would be therapeutically targeted to harness the power of NK cells against diverse cancer cells that express heterogeneous ligands for NK cell receptors. Recent advances in understanding the activation of NK cells have revealed promising candidates in this category. Targeting such molecular checkpoints will facilitate NK cell activation by lowering activation thresholds, thereby providing therapeutic strategies that optimize NK cell reactivity against cancer. |*Lymphocyte Activation [MESH] |Animals [MESH] |Cytokines/immunology [MESH] |Humans [MESH] |Immunotherapy/*methods [MESH] |Killer Cells, Natural/*immunology [MESH]Molecular checkpoints controlling natural killer cell activation and t(epmc).pdf DeepDyve Pubget Overpricing