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10.1038/emm.2016.169 http://scihub22266oqcxt.onion/10.1038/emm.2016.169 C5382560!5382560!28360429     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Mol+Med 2017 ; 49 (3): e310- Nephropedia Template TP {{tp|p=28360429|t=2017. Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy |pdf=|usr=}}{{28360429}} gab.com Text Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28360429 #FOAvip Interleukin (IL)-20, a proinflammatory cytokine of the IL-10 family, is involved in acute and chronic renal failure. The aim of this study was to elucidate the role of IL-20 during diabetic nephropathy development. We found that IL-20 and its receptor IL-20R1 were upregulated in the kidneys of mice and rats with STZ-induced diabetes. In vitro, IL-20 induced MMP-9, MCP-1, TGF-?1 and VEGF expression in podocytes. IL-20 was upregulated by hydrogen peroxide, high-dose glucose and TGF-?1. In addition, IL-20 induced apoptosis in podocytes by activating caspase-8. In STZ-induced early diabetic nephropathy, IL-20R1-deficient mice had lower blood glucose and serum BUN levels and a smaller glomerular area than did wild-type controls. Anti-IL-20 monoclonal antibody (7E) treatment reduced blood glucose and the glomerular area and improved renal functions in mice in the early stage of STZ-induced diabetic nephropathy. ELISA showed that the serum IL-20 level was higher in patients with diabetes mellitus than in healthy controls. The findings of this study suggest that IL-20 induces cell apoptosis of podocytes and plays a role in the pathogenesis of early diabetic nephropathy. Twit Text FOAVip Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28360429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28360429 #FOAvip English Wikipedia <ref>{{Cite pmid|28360429}}</ref> Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy #MMPMID28360429 Hsu YH; Li HH; Sung JM; Chen WY; Hou YC; Weng YH; Lai WT; Wu CH; Chang MS Exp Mol Med 2017[Mar]; 49 (3): e310- PMID28360429show ga Interleukin (IL)-20, a proinflammatory cytokine of the IL-10 family, is involved in acute and chronic renal failure. The aim of this study was to elucidate the role of IL-20 during diabetic nephropathy development. We found that IL-20 and its receptor IL-20R1 were upregulated in the kidneys of mice and rats with STZ-induced diabetes. In vitro, IL-20 induced MMP-9, MCP-1, TGF-?1 and VEGF expression in podocytes. IL-20 was upregulated by hydrogen peroxide, high-dose glucose and TGF-?1. In addition, IL-20 induced apoptosis in podocytes by activating caspase-8. In STZ-induced early diabetic nephropathy, IL-20R1-deficient mice had lower blood glucose and serum BUN levels and a smaller glomerular area than did wild-type controls. Anti-IL-20 monoclonal antibody (7E) treatment reduced blood glucose and the glomerular area and improved renal functions in mice in the early stage of STZ-induced diabetic nephropathy. ELISA showed that the serum IL-20 level was higher in patients with diabetes mellitus than in healthy controls. The findings of this study suggest that IL-20 induces cell apoptosis of podocytes and plays a role in the pathogenesis of early diabetic nephropathy. äInterleukin-20 targets podocytes and is upregulated in experimental mu(epmc).pdf DeepDyve Pubget Overpricing