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10.1038/emm.2016.167 http://scihub22266oqcxt.onion/10.1038/emm.2016.167 C5382558!5382558 !28303029     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28303029 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Mol+Med 2017 ; 49 (3 ): e302 Nephropedia Template TP {{tp|p=28303029 |t=2017. TMF and glycitin act synergistically on keratinocytes and fibroblasts to promote wound healing and anti-scarring activity |pdf=|usr=}}{{28303029 }} gab.com Text TMF and glycitin act synergistically on keratinocytes and fibroblasts to promote wound healing and anti-scarring activity JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28303029 #FOAvip Keratinocyte-fibroblast interactions are critical for skin repair after injury. During the proliferative phase of wound healing, proliferation, migration and differentiation of these cells are the major mechanisms leading to tissue remodeling. We have previously reported that glycitin, a major soy isoflavone, stimulates dermal fibroblast proliferation; and the phytochemical, 4',6,7-trimethoxyisoflavone (TMF), induces migration of HaCaT keratinocyte cells. We therefore investigated whether these compounds display synergistic effects on skin cells during wound healing in vitro and in vivo. Co-treatment with TMF and glycitin synergistically promotes the proliferation and migration of both keratinocytes and dermal fibroblasts, with a 1:1 ratio of these compounds showing the greatest efficacy in our co-culture system. This keratinocyte-fibroblast interaction occurred via the secretion of TGF-?, and the induction of differentiation and proliferation was confirmed in both indirect and direct co-culture assays. In an excisional and burn wound animal model, mice treated with a 1:1 ratio of TMF and glycitin showed faster wound closure, regeneration and scar reduction than even the positive control drug. These data indicate that two isoflavones, TMF and glycitin, act synergistically to promote wound healing and anti-scarring and could potentially be developed together as a bioactive therapeutic for wound treatment. Twit Text FOAVip TMF and glycitin act synergistically on keratinocytes and fibroblasts to promote wound healing and anti-scarring activity ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28303029 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28303029 #FOAvip English Wikipedia <ref>{{Cite pmid|28303029 }}</ref> TMF and glycitin act synergistically on keratinocytes and fibroblasts to promote wound healing and anti-scarring activity #MMPMID28303029 Seo GY ; Lim Y ; Koh D ; Huh JS ; Hyun C ; Kim YM ; Cho M Exp Mol Med 2017[Mar]; 49 (3 ): e302 PMID28303029 show ga Keratinocyte-fibroblast interactions are critical for skin repair after injury. During the proliferative phase of wound healing, proliferation, migration and differentiation of these cells are the major mechanisms leading to tissue remodeling. We have previously reported that glycitin, a major soy isoflavone, stimulates dermal fibroblast proliferation; and the phytochemical, 4',6,7-trimethoxyisoflavone (TMF), induces migration of HaCaT keratinocyte cells. We therefore investigated whether these compounds display synergistic effects on skin cells during wound healing in vitro and in vivo. Co-treatment with TMF and glycitin synergistically promotes the proliferation and migration of both keratinocytes and dermal fibroblasts, with a 1:1 ratio of these compounds showing the greatest efficacy in our co-culture system. This keratinocyte-fibroblast interaction occurred via the secretion of TGF-?, and the induction of differentiation and proliferation was confirmed in both indirect and direct co-culture assays. In an excisional and burn wound animal model, mice treated with a 1:1 ratio of TMF and glycitin showed faster wound closure, regeneration and scar reduction than even the positive control drug. These data indicate that two isoflavones, TMF and glycitin, act synergistically to promote wound healing and anti-scarring and could potentially be developed together as a bioactive therapeutic for wound treatment. |Animals [MESH] |Burns/*drug therapy [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Cicatrix/*drug therapy [MESH] |Female [MESH] |Fibroblasts/*drug effects/metabolism [MESH] |Humans [MESH] |Isoflavones/*pharmacology/therapeutic use [MESH] |Keratinocytes/*drug effects/metabolism [MESH] |Lymphotoxin-alpha/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH]TMF and glycitin act synergistically on keratinocytes and fibroblasts (epmc).pdf DeepDyve Pubget Overpricing