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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ann+Clin+Microbiol+Antimicrob
2017 ; 16
(1
): 24
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gab.com Text
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The efficacy and safety of tigecycline for the treatment of bloodstream
infections: a systematic review and meta-analysis
#MMPMID28381268
Wang J
; Pan Y
; Shen J
; Xu Y
Ann Clin Microbiol Antimicrob
2017[Apr]; 16
(1
): 24
PMID28381268
show ga
Patients with bloodstream infections (BSI) are associated with high mortality
rates. Due to tigecycline has shown excellent in vitro activity against most
pathogens, tigecycline is selected as one of the candidate drugs for the
treatment of multidrug-resistant organisms infections. The purpose of this study
was to evaluate the effectiveness and safety of the use of tigecycline for the
treatment of patients with BSI. The PubMed and Embase databases were
systematically searched, to identify published studies, and we searched clinical
trial registries to identify completed unpublished studies, the results of which
were obtained through the manufacturer. The primary outcome was mortality, and
the secondary outcomes were the rate of clinical cure and microbiological
success. 24 controlled studies were included in this systematic review. All-cause
mortality was lower with tigecycline than with control antibiotic agents, but the
difference was not significant (OR 0.85, [95% confidence interval (CI) 0.31-2.33;
P = 0.745]). Clinical cure was significantly higher with tigecycline groups (OR
1.76, [95% CI 1.26-2.45; P = 0.001]). Eradication efficiency did not differ
between tigecycline and control regimens, but the sample size for these
comparisons was small. Subgroup analyses showed good clinical cure result in
bacteremia patients with CAP. Tigecycline monotherapy was associated with a OR of
2.73 (95% CI 1.53-4.87) for mortality compared with tigecycline combination
therapy (6 studies; 250 patients), without heterogeneity. Five studies reporting
on 398 patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae
BSI showed significantly lower mortality in the tigecycline arm than in the
control arm. The combined treatment with tigecycline may be considered the
optimal option for severely ill patients with BSI.
|Anti-Bacterial Agents/*adverse effects/*therapeutic use
[MESH]
|Bacteremia/*drug therapy
[MESH]
|Humans
[MESH]
|Minocycline/adverse effects/*analogs & derivatives/therapeutic use
[MESH]
free
free
free
