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10.1111/imm.12707 http://scihub22266oqcxt.onion/10.1111/imm.12707 C5382347!5382347!28054346     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunology 2017 ; 151 (1): 71-80 Nephropedia Template TP {{tp|p=28054346|t=2017. Optimized logic rules reveal interferon???induced modes regulated by histone deacetylases and protein tyrosine phosphatases |pdf=|usr=}}{{28054346}} gab.com Text Optimized logic rules reveal interferon induced modes regulated by histone deacetylases and protein tyrosine phosphatases JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=28054346 #FOAvip The pro?inflammatory cytokine interferon?? (IFN??) is critical for activating innate and adaptive immunity against tumours and intracellular pathogens. Interferon?? is secreted at the fetal?maternal interface in pregnant women and mice. The outer layer of the placenta in contact with maternal blood is composed of semi?allogeneic trophoblast cells, which constitute the fetal component of the fetal?maternal interface. The simultaneous presence of pro?inflammatory IFN?? and trophoblast cells at the fetal?maternal interface appears to represent an immunological paradox, for trophoblastic responses to IFN?? could potentially lead to activation of maternal immunity and subsequent attack of the placenta. However, our previous studies demonstrate that IFN?? responsive gene (IRG) expression is negatively regulated in human and mouse trophoblast cells. In human cytotrophoblast and trophoblast?derived choriocarcinoma cells, janus kinase signalling is blocked by protein tyrosine phosphatases (PTPs), whereas in mouse trophoblast, histone deacetylases (HDACs) inhibit IRG expression. Here, we used genome?wide transcriptional profiling to investigate the collective roles of PTPs and HDACs on regulation of IRG expression in human choriocarcinoma cells. Logic?rules were optimized to derive regulatory modes governing gene expression patterns observed upon different combinations of treatment with PTP and HDAC inhibitors. The results demonstrate that IRGs can be divided into several categories in human choriocarcinoma cells, each of which is subject to distinct mechanisms of repression. Hence, the regulatory modes identified in this study suggest that human trophoblast and choriocarcinoma cells may evade the potentially deleterious consequences of exposure to IFN?? by using several overlapping mechanisms to block IRG expression. Twit Text FOAVip Optimized logic rules reveal interferon induced modes regulated by histone deacetylases and protein tyrosine phosphatases ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=28054346 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28054346 #FOAvip English Wikipedia <ref>{{Cite pmid|28054346}}</ref> Optimized logic rules reveal interferon???induced modes regulated by histone deacetylases and protein tyrosine phosphatases #MMPMID28054346 Van Twisk D; Murphy SP; Thakar J Immunology 2017[May]; 151 (1): 71-80 PMID28054346show ga The pro?inflammatory cytokine interferon?? (IFN??) is critical for activating innate and adaptive immunity against tumours and intracellular pathogens. Interferon?? is secreted at the fetal?maternal interface in pregnant women and mice. The outer layer of the placenta in contact with maternal blood is composed of semi?allogeneic trophoblast cells, which constitute the fetal component of the fetal?maternal interface. The simultaneous presence of pro?inflammatory IFN?? and trophoblast cells at the fetal?maternal interface appears to represent an immunological paradox, for trophoblastic responses to IFN?? could potentially lead to activation of maternal immunity and subsequent attack of the placenta. However, our previous studies demonstrate that IFN?? responsive gene (IRG) expression is negatively regulated in human and mouse trophoblast cells. In human cytotrophoblast and trophoblast?derived choriocarcinoma cells, janus kinase signalling is blocked by protein tyrosine phosphatases (PTPs), whereas in mouse trophoblast, histone deacetylases (HDACs) inhibit IRG expression. Here, we used genome?wide transcriptional profiling to investigate the collective roles of PTPs and HDACs on regulation of IRG expression in human choriocarcinoma cells. Logic?rules were optimized to derive regulatory modes governing gene expression patterns observed upon different combinations of treatment with PTP and HDAC inhibitors. The results demonstrate that IRGs can be divided into several categories in human choriocarcinoma cells, each of which is subject to distinct mechanisms of repression. Hence, the regulatory modes identified in this study suggest that human trophoblast and choriocarcinoma cells may evade the potentially deleterious consequences of exposure to IFN?? by using several overlapping mechanisms to block IRG expression. äOptimized logic rules reveal interferon???induced modes regulated by h(epmc).pdf DeepDyve Pubget Overpricing