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10.1038/ncomms15062 http://scihub22266oqcxt.onion/10.1038/ncomms15062 C5382287!5382287 !28375200     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28375200 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 15062 Nephropedia Template TP {{tp|p=28375200 |t=2017. Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior |pdf=|usr=}}{{28375200 }} gab.com Text Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28375200 #FOAvip There is increasing concern about potential long-term effects of antibiotics on children's health. Epidemiological studies have revealed that early-life antibiotic exposure can increase the risk of developing immune and metabolic diseases, and rodent studies have shown that administration of high doses of antibiotics has long-term effects on brain neurochemistry and behaviour. Here we investigate whether low-dose penicillin in late pregnancy and early postnatal life induces long-term effects in the offspring of mice. We find that penicillin has lasting effects in both sexes on gut microbiota, increases cytokine expression in frontal cortex, modifies blood-brain barrier integrity and alters behaviour. The antibiotic-treated mice exhibit impaired anxiety-like and social behaviours, and display aggression. Concurrent supplementation with Lactobacillus rhamnosus JB-1 prevents some of these alterations. These results warrant further studies on the potential role of early-life antibiotic use in the development of neuropsychiatric disorders, and the possible attenuation of these by beneficial bacteria. Twit Text FOAVip Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28375200 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28375200 #FOAvip English Wikipedia <ref>{{Cite pmid|28375200 }}</ref> Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior #MMPMID28375200 Leclercq S ; Mian FM ; Stanisz AM ; Bindels LB ; Cambier E ; Ben-Amram H ; Koren O ; Forsythe P ; Bienenstock J Nat Commun 2017[Apr]; 8 (ä): 15062 PMID28375200 show ga There is increasing concern about potential long-term effects of antibiotics on children's health. Epidemiological studies have revealed that early-life antibiotic exposure can increase the risk of developing immune and metabolic diseases, and rodent studies have shown that administration of high doses of antibiotics has long-term effects on brain neurochemistry and behaviour. Here we investigate whether low-dose penicillin in late pregnancy and early postnatal life induces long-term effects in the offspring of mice. We find that penicillin has lasting effects in both sexes on gut microbiota, increases cytokine expression in frontal cortex, modifies blood-brain barrier integrity and alters behaviour. The antibiotic-treated mice exhibit impaired anxiety-like and social behaviours, and display aggression. Concurrent supplementation with Lactobacillus rhamnosus JB-1 prevents some of these alterations. These results warrant further studies on the potential role of early-life antibiotic use in the development of neuropsychiatric disorders, and the possible attenuation of these by beneficial bacteria. |*Social Behavior [MESH] |Animals [MESH] |Anti-Bacterial Agents/administration & dosage/toxicity [MESH] |Anxiety/chemically induced/physiopathology/prevention & control [MESH] |Cytokines/*metabolism [MESH] |Female [MESH] |Frontal Lobe/drug effects/*metabolism [MESH] |Gastrointestinal Microbiome/drug effects/*physiology [MESH] |Lactobacillus/physiology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Penicillin V/*administration & dosage/toxicity [MESH] |Pregnancy [MESH] |Prenatal Exposure Delayed Effects/chemically induced/*physiopathology/prevention & control [MESH]Low-dose penicillin in early life induces long-term changes in murine (epmc).pdf DeepDyve Pubget Overpricing