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10.1038/ncomms14930 http://scihub22266oqcxt.onion/10.1038/ncomms14930 C5382274!5382274!28374737     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28374737|t=2017. Extinct type of human parvovirus B19 persists in tonsillar B cells |pdf=|usr=}}{{28374737}} gab.com Text Extinct type of human parvovirus B19 persists in tonsillar B cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28374737 #FOAvip Parvovirus B19 (B19V) DNA persists lifelong in human tissues, but the cell type harbouring it remains unclear. We here explore B19V DNA distribution in B, T and monocyte cell lineages of recently excised tonsillar tissues from 77 individuals with an age range of 2?69 years. We show that B19V DNA is most frequent and abundant among B cells, and within them we find a B19V genotype that vanished from circulation >40 years ago. Since re-infection or re-activation are unlikely with this virus type, this finding supports the maintenance of pathogen-specific humoral immune responses as a consequence of B-cell long-term survival rather than continuous replenishment of the memory pool. Moreover, we demonstrate the mechanism of B19V internalization to be antibody dependent in two B-cell lines as well as in ex vivo isolated tonsillar B cells. This study provides direct evidence for a cell type accountable for B19V DNA tissue persistence. Twit Text FOAVip Extinct type of human parvovirus B19 persists in tonsillar B cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28374737 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28374737 #FOAvip English Wikipedia <ref>{{Cite pmid|28374737}}</ref> Extinct type of human parvovirus B19 persists in tonsillar B cells #MMPMID28374737 Pyöriä L; Toppinen M; Mäntylä E; Hedman L; Aaltonen LM; Vihinen-Ranta M; Ilmarinen T; Söderlund-Venermo M; Hedman K; Perdomo MF Nat Commun 2017[]; 8 (ä): ä PMID28374737show ga Parvovirus B19 (B19V) DNA persists lifelong in human tissues, but the cell type harbouring it remains unclear. We here explore B19V DNA distribution in B, T and monocyte cell lineages of recently excised tonsillar tissues from 77 individuals with an age range of 2?69 years. We show that B19V DNA is most frequent and abundant among B cells, and within them we find a B19V genotype that vanished from circulation >40 years ago. Since re-infection or re-activation are unlikely with this virus type, this finding supports the maintenance of pathogen-specific humoral immune responses as a consequence of B-cell long-term survival rather than continuous replenishment of the memory pool. Moreover, we demonstrate the mechanism of B19V internalization to be antibody dependent in two B-cell lines as well as in ex vivo isolated tonsillar B cells. This study provides direct evidence for a cell type accountable for B19V DNA tissue persistence. äExtinct type of human parvovirus B19 persists in tonsillar B cells (epmc).pdf DeepDyve Pubget Overpricing