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10.1038/ncomms14861 http://scihub22266oqcxt.onion/10.1038/ncomms14861 C5382271!5382271 !28367989     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28367989 &cmd=llinks): Failed to open stream: HTTP request failed! 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The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA |pdf=|usr=}}{{28367989 }} gab.com Text The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28367989 #FOAvip Termination of RNA polymerase II (Pol II) transcription is an important step in the transcription cycle, which involves the dislodgement of polymerase from DNA, leading to release of a functional transcript. Recent studies have identified the key players required for this process and showed that a common feature of these proteins is a conserved domain that interacts with the phosphorylated C-terminus of Pol II (CTD-interacting domain, CID). However, the mechanism by which transcription termination is achieved is not understood. Using genome-wide methods, here we show that the fission yeast CID-protein Seb1 is essential for termination of protein-coding and non-coding genes through interaction with S2-phosphorylated Pol II and nascent RNA. Furthermore, we present the crystal structures of the Seb1 CTD- and RNA-binding modules. Unexpectedly, the latter reveals an intertwined two-domain arrangement of a canonical RRM and second domain. These results provide important insights into the mechanism underlying eukaryotic transcription termination. Twit Text FOAVip The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28367989 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28367989 #FOAvip English Wikipedia <ref>{{Cite pmid|28367989 }}</ref> The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA #MMPMID28367989 Wittmann S ; Renner M ; Watts BR ; Adams O ; Huseyin M ; Baejen C ; El Omari K ; Kilchert C ; Heo DH ; Kecman T ; Cramer P ; Grimes JM ; Vasiljeva L Nat Commun 2017[Apr]; 8 (ä): 14861 PMID28367989 show ga Termination of RNA polymerase II (Pol II) transcription is an important step in the transcription cycle, which involves the dislodgement of polymerase from DNA, leading to release of a functional transcript. Recent studies have identified the key players required for this process and showed that a common feature of these proteins is a conserved domain that interacts with the phosphorylated C-terminus of Pol II (CTD-interacting domain, CID). However, the mechanism by which transcription termination is achieved is not understood. Using genome-wide methods, here we show that the fission yeast CID-protein Seb1 is essential for termination of protein-coding and non-coding genes through interaction with S2-phosphorylated Pol II and nascent RNA. Furthermore, we present the crystal structures of the Seb1 CTD- and RNA-binding modules. Unexpectedly, the latter reveals an intertwined two-domain arrangement of a canonical RRM and second domain. These results provide important insights into the mechanism underlying eukaryotic transcription termination. |*Conserved Sequence [MESH] |*Transcription Termination, Genetic [MESH] |Base Sequence [MESH] |Cell Survival [MESH] |Crystallography, X-Ray [MESH] |Genes, Fungal [MESH] |Models, Biological [MESH] |Models, Molecular [MESH] |Nuclear Proteins/chemistry/*metabolism [MESH] |Open Reading Frames/genetics [MESH] |Phosphorylation [MESH] |Point Mutation/genetics [MESH] |Protein Binding [MESH] |Protein Domains [MESH] |RNA Polymerase II/*metabolism [MESH] |RNA, Fungal/*metabolism [MESH] |RNA-Binding Proteins/chemistry/*metabolism [MESH] |Saccharomyces cerevisiae Proteins/metabolism [MESH] |Schizosaccharomyces pombe Proteins/chemistry/*metabolism [MESH] |Schizosaccharomyces/*genetics [MESH] |Structure-Activity Relationship [MESH]The conserved protein Seb1 drives transcription termination by binding(epmc).pdf DeepDyve Pubget Overpricing