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10.1038/ncomms14830 http://scihub22266oqcxt.onion/10.1038/ncomms14830 C5382270!5382270 !28368000     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28368000 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 14830 Nephropedia Template TP {{tp|p=28368000 |t=2017. Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses |pdf=|usr=}}{{28368000 }} gab.com Text Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28368000 #FOAvip Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating residues are phosphorylated both before and after Toll-like receptor (TLR) stimulation. Fyn or Lyn genetic ablation as well as treatment with SFK inhibitors ablate pDC (but not conventional DC) responses both in vitro and in vivo. Inhibition of SFK activity not only alters TLR-ligand localization and inhibits downstream signalling events, but, independent of ex-vivo TLR stimulation, also affects constitutive phosphorylation of BCAP, an adaptor protein bridging PI3K and TLR pathways. Our data identify Fyn and Lyn as important factors that promote pDC responses, describe the mechanisms involved and highlight a tonic SFK-mediated signalling that precedes pathogen encounter, raising the possibility that small molecules targeting SFKs could modulate pDC responses in human diseases. Twit Text FOAVip Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28368000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28368000 #FOAvip English Wikipedia <ref>{{Cite pmid|28368000 }}</ref> Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses #MMPMID28368000 Dallari S ; Macal M ; Loureiro ME ; Jo Y ; Swanson L ; Hesser C ; Ghosh P ; Zuniga EI Nat Commun 2017[Apr]; 8 (ä): 14830 PMID28368000 show ga Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating residues are phosphorylated both before and after Toll-like receptor (TLR) stimulation. Fyn or Lyn genetic ablation as well as treatment with SFK inhibitors ablate pDC (but not conventional DC) responses both in vitro and in vivo. Inhibition of SFK activity not only alters TLR-ligand localization and inhibits downstream signalling events, but, independent of ex-vivo TLR stimulation, also affects constitutive phosphorylation of BCAP, an adaptor protein bridging PI3K and TLR pathways. Our data identify Fyn and Lyn as important factors that promote pDC responses, describe the mechanisms involved and highlight a tonic SFK-mediated signalling that precedes pathogen encounter, raising the possibility that small molecules targeting SFKs could modulate pDC responses in human diseases. |Animals [MESH] |Carrier Proteins/metabolism [MESH] |Cytokines/biosynthesis [MESH] |Cytomegalovirus Infections/pathology/virology [MESH] |Dendritic Cells/drug effects/*enzymology [MESH] |Endosomes/drug effects/metabolism [MESH] |Enzyme Activation/drug effects [MESH] |Humans [MESH] |Ligands [MESH] |Mice, Inbred C57BL [MESH] |Muromegalovirus/physiology [MESH] |Phosphorylation/drug effects [MESH] |Protein Transport/drug effects [MESH] |Proto-Oncogene Proteins c-fyn/*metabolism [MESH] |Pyrimidines/pharmacology [MESH] |Signal Transduction/drug effects [MESH] |TOR Serine-Threonine Kinases/metabolism [MESH] |Toll-Like Receptors/metabolism [MESH]Src family kinases Fyn and Lyn are constitutively activated and mediat(epmc).pdf DeepDyve Pubget Overpricing