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10.1016/j.celrep.2017.03.011 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.03.011 C5382239!5382239!28355557     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2017 ; 18 (13): 3043-51 Nephropedia Template TP {{tp|p=28355557|t=2017. Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet |pdf=|usr=}}{{28355557}} gab.com Text Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28355557 #FOAvip AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in response to energy demand. We identified a mutation in the ?1 subunit (?1D316A) that leads to activation of AMPK. We generated mice with this mutation to study the effect of chronic liver-specific activation of AMPK in vivo. Primary hepatocytes isolated from these mice have reduced gluconeogenesis and fatty acid synthesis, but there is no effect on fatty acid oxidation compared to cells from wild-type mice. Liver-specific activation of AMPK decreases lipogenesis in vivo and completely protects against hepatic steatosis when mice are fed a high-fructose diet. Our findings demonstrate that liver-specific activation of AMPK is sufficient to protect against hepatic triglyceride accumulation, a hallmark of non-alcoholic fatty liver disease (NAFLD). These results emphasize the clinical relevance of activating AMPK in the liver to combat NAFLD and potentially other associated complications (e.g., cirrhosis and hepatocellular carcinoma). Twit Text FOAVip Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28355557 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28355557 #FOAvip English Wikipedia <ref>{{Cite pmid|28355557}}</ref> Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet #MMPMID28355557 Woods A; Williams JR; Muckett PJ; Mayer FV; Liljevald M; Bohlooly-Y M; Carling D Cell Rep 2017[Mar]; 18 (13): 3043-51 PMID28355557show ga AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in response to energy demand. We identified a mutation in the ?1 subunit (?1D316A) that leads to activation of AMPK. We generated mice with this mutation to study the effect of chronic liver-specific activation of AMPK in vivo. Primary hepatocytes isolated from these mice have reduced gluconeogenesis and fatty acid synthesis, but there is no effect on fatty acid oxidation compared to cells from wild-type mice. Liver-specific activation of AMPK decreases lipogenesis in vivo and completely protects against hepatic steatosis when mice are fed a high-fructose diet. Our findings demonstrate that liver-specific activation of AMPK is sufficient to protect against hepatic triglyceride accumulation, a hallmark of non-alcoholic fatty liver disease (NAFLD). These results emphasize the clinical relevance of activating AMPK in the liver to combat NAFLD and potentially other associated complications (e.g., cirrhosis and hepatocellular carcinoma). äLiver-Specific Activation of AMPK Prevents Steatosis on a High-Fructos(epmc).pdf DeepDyve Pubget Overpricing