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10.3389/fimmu.2017.00409 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00409 C5382190!5382190!28428787     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28428787|t=2017. A Possible Role for Idiotype/Anti-idiotype B?T Cell Interactions in Maintaining Immune Memory |pdf=|usr=}}{{28428787}} gab.com Text A Possible Role for Idiotype/Anti-idiotype B T Cell Interactions in Maintaining Immune Memory JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28428787 #FOAvip Variable regions of both B-cell receptors (BCRs) and T-cell receptors (TCRs) are completely formed in the postnatal period, and, consequently, no innate immune tolerance against these structures exists in adulthood. Indeed, antibodies (Abs) specific to TCRs have been found in both animals and humans. These facts clearly indicate the existence of B cells able to directly interact with T cells through binding of BCRs to TCRs without implicating major histocompatibility complex molecules. A novel paradigm is proposed in that the immune memory is based on idiotype/anti-idiotype interactions occurring between BCRs and TCRs following clearance of the antigen that elicited immune responses. It is envisaged that direct contact between memory T and B cells could provide co-stimulatory signals needed to sustain viability, growth, and differentiation of the interacting immune cells. In contrast, plasma cells originating from memory B-cells could produce anti-TCR Abs that inhibit direct BCR-to-TCR interactions, thereby downregulating the B- to T-cell contact-based immune memory via a negative feedback mechanism. Twit Text FOAVip A Possible Role for Idiotype/Anti-idiotype B T Cell Interactions in Maintaining Immune Memory ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28428787 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28428787 #FOAvip English Wikipedia <ref>{{Cite pmid|28428787}}</ref> A Possible Role for Idiotype/Anti-idiotype B?T Cell Interactions in Maintaining Immune Memory #MMPMID28428787 Seledtsov VI; Seledtsova GV Front Immunol 2017[]; 8 (ä): ä PMID28428787show ga Variable regions of both B-cell receptors (BCRs) and T-cell receptors (TCRs) are completely formed in the postnatal period, and, consequently, no innate immune tolerance against these structures exists in adulthood. Indeed, antibodies (Abs) specific to TCRs have been found in both animals and humans. These facts clearly indicate the existence of B cells able to directly interact with T cells through binding of BCRs to TCRs without implicating major histocompatibility complex molecules. A novel paradigm is proposed in that the immune memory is based on idiotype/anti-idiotype interactions occurring between BCRs and TCRs following clearance of the antigen that elicited immune responses. It is envisaged that direct contact between memory T and B cells could provide co-stimulatory signals needed to sustain viability, growth, and differentiation of the interacting immune cells. In contrast, plasma cells originating from memory B-cells could produce anti-TCR Abs that inhibit direct BCR-to-TCR interactions, thereby downregulating the B- to T-cell contact-based immune memory via a negative feedback mechanism. äA Possible Role for Idiotype/Anti-idiotype B?T Cell Interactions in Ma(epmc).pdf DeepDyve Pubget Overpricing