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10.4049/jimmunol.1601966 http://scihub22266oqcxt.onion/10.4049/jimmunol.1601966 C5381961!5381961 !28264971     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28264971 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2017 ; 198 (8 ): 3127-3135 Nephropedia Template TP {{tp|p=28264971 |t=2017. The Lower Limit of Regulatory CD4(+) Foxp3(+) TCR? Repertoire Diversity Required To Control Autoimmunity |pdf=|usr=}}{{28264971 }} gab.com Text The Lower Limit of Regulatory CD4(+) Foxp3(+) TCR Repertoire Diversity Required To Control Autoimmunity JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28264971 #FOAvip The TCR repertoire of regulatory T cells (Tregs) is highly diverse. The relevance of this diversity to maintain self-tolerance remains unknown. We established a model where the TCR repertoire of normal polyclonal Tregs was limited by serial transfers into IL-2R?(-/-) mice, which lack functional Tregs. After a primary transfer, the donor Treg TCR repertoire was substantially narrowed, yet the recipients remained autoimmune-free. Importantly, upon purification and transfer of donor-derived Tregs from an individual primary recipient into neonatal IL-2R?(-/-) mice, the secondary recipients developed autoimmunity. In this study, the Treg TCR? repertoire was reshaped and further narrowed. In contrast, secondary IL-2R? recipients showed fewer symptoms of autoimmunity when they received donor Tregs that were premixed from several primary recipients to increase their TCR? repertoire diversity. About 8-11% of the Treg TCR? repertoire was estimated to be the minimum required to establish and maintain tolerance in primary IL-2R?(-/-) recipients. Collectively, these data quantify where limitations imposed on the Treg TCR? repertoire results in a population of Tregs that cannot fully suppress polyclonal autoreactive T cells. Our data favor a model where the high diversity of the Treg TCR provides a mechanism for Tregs to actively adapt and effectively suppress autoreactive T cells, which are not fixed, but are evolving as they encounter self-antigens. Twit Text FOAVip The Lower Limit of Regulatory CD4(+) Foxp3(+) TCR Repertoire Diversity Required To Control Autoimmunity ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28264971 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28264971 #FOAvip English Wikipedia <ref>{{Cite pmid|28264971 }}</ref> The Lower Limit of Regulatory CD4(+) Foxp3(+) TCR? Repertoire Diversity Required To Control Autoimmunity #MMPMID28264971 Yu A ; Dee MJ ; Adeegbe D ; Dwyer CJ ; Altman NH ; Malek TR J Immunol 2017[Apr]; 198 (8 ): 3127-3135 PMID28264971 show ga The TCR repertoire of regulatory T cells (Tregs) is highly diverse. The relevance of this diversity to maintain self-tolerance remains unknown. We established a model where the TCR repertoire of normal polyclonal Tregs was limited by serial transfers into IL-2R?(-/-) mice, which lack functional Tregs. After a primary transfer, the donor Treg TCR repertoire was substantially narrowed, yet the recipients remained autoimmune-free. Importantly, upon purification and transfer of donor-derived Tregs from an individual primary recipient into neonatal IL-2R?(-/-) mice, the secondary recipients developed autoimmunity. In this study, the Treg TCR? repertoire was reshaped and further narrowed. In contrast, secondary IL-2R? recipients showed fewer symptoms of autoimmunity when they received donor Tregs that were premixed from several primary recipients to increase their TCR? repertoire diversity. About 8-11% of the Treg TCR? repertoire was estimated to be the minimum required to establish and maintain tolerance in primary IL-2R?(-/-) recipients. Collectively, these data quantify where limitations imposed on the Treg TCR? repertoire results in a population of Tregs that cannot fully suppress polyclonal autoreactive T cells. Our data favor a model where the high diversity of the Treg TCR provides a mechanism for Tregs to actively adapt and effectively suppress autoreactive T cells, which are not fixed, but are evolving as they encounter self-antigens. |Animals [MESH] |Autoimmunity/*immunology [MESH] |CD4-Positive T-Lymphocytes/*immunology [MESH] |Cell Separation [MESH] |Flow Cytometry [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Receptors, Antigen, T-Cell, alpha-beta/*immunology [MESH]The Lower Limit of Regulatory CD4(+) Foxp3(+) TCR? Repertoire Diversit(epmc).pdf DeepDyve Pubget Overpricing