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10.1038/nrc.2016.36 http://scihub22266oqcxt.onion/10.1038/nrc.2016.36 C5381938!5381938!27079802     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Cancer 2016 ; 16 (5): 275-87 Nephropedia Template TP {{tp|p=27079802|t=2016. Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy |pdf=|usr=}}{{27079802}} gab.com Text Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy JO: Nat Rev Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27079802 #FOAvip With recent approvals for multiple therapeutic antibodies that block cytotoxic T lymphocyte associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) in melanoma, non-small-cell lung cancer and kidney cancer, and additional immune checkpoints being targeted clinically, many questions still remain regarding the optimal use of drugs that block these checkpoint pathways. Defining biomarkers that predict therapeutic effects and adverse events is a crucial mandate, highlighted by recent approvals for two PDL1 diagnostic tests. Here, we discuss biomarkers for anti-PD1 therapy based on immunological, genetic and virological criteria. The unique biology of the CTLA4 immune checkpoint, compared with PD1, requires a different approach to biomarker development. Mechanism-based insights from such studies may guide the design of synergistic treatment combinations based on immune checkpoint blockade. Twit Text FOAVip Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy ????Nat Rev Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27079802 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27079802 #FOAvip English Wikipedia <ref>{{Cite pmid|27079802}}</ref> Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy #MMPMID27079802 Topalian SL; Taube JM; Anders RA; Pardoll DM Nat Rev Cancer 2016[May]; 16 (5): 275-87 PMID27079802show ga With recent approvals for multiple therapeutic antibodies that block cytotoxic T lymphocyte associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) in melanoma, non-small-cell lung cancer and kidney cancer, and additional immune checkpoints being targeted clinically, many questions still remain regarding the optimal use of drugs that block these checkpoint pathways. Defining biomarkers that predict therapeutic effects and adverse events is a crucial mandate, highlighted by recent approvals for two PDL1 diagnostic tests. Here, we discuss biomarkers for anti-PD1 therapy based on immunological, genetic and virological criteria. The unique biology of the CTLA4 immune checkpoint, compared with PD1, requires a different approach to biomarker development. Mechanism-based insights from such studies may guide the design of synergistic treatment combinations based on immune checkpoint blockade. äMechanism-driven biomarkers to guide immune checkpoint blockade in can(epmc).pdf DeepDyve Pubget Overpricing