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10.1371/journal.pone.0174523 http://scihub22266oqcxt.onion/10.1371/journal.pone.0174523 C5381882!5381882 !28380007     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28380007 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (4 ): e0174523 Nephropedia Template TP {{tp|p=28380007 |t=2017. In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery |pdf=|usr=}}{{28380007 }} gab.com Text In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28380007 #FOAvip BACKGROUND: Influenza virus infection is a major threat to human health. Small interfering RNA (siRNA) is a promising approach for the prevention and treatment of viral infections. In this study, we constructed a series of DNA vector-based short hairpin RNAs (shRNAs) that target various genes of the influenza A virus using the polymerase III U6-RNA promoter to prevent influenza virus infection in vitro and in a mouse model. RESULTS: Three sets of DNA vector-based shRNA, two targeting genes encoding the polymerase acidic protein (PA) and one targeting polymerase basic protein 2 (PB2), efficiently inhibited the replication of influenza virus A/WSN/33(H1N1) in vitro. We also successfully prevented influenza virus A/WSN/33(H1N1) infection in a C57BL/6 mouse model by intratracheal delivery of anti-PB2 shRNA. CONCLUSIONS: Our findings suggest that the PB2-targeting shRNA plasmid showed potential for use as an RNAi-based therapeutic for influenza virus infection. Twit Text FOAVip In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28380007 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28380007 #FOAvip English Wikipedia <ref>{{Cite pmid|28380007 }}</ref> In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery #MMPMID28380007 Huang DT ; Lu CY ; Shao PL ; Chang LY ; Wang JY ; Chang YH ; Lai MJ ; Chi YH ; Huang LM PLoS One 2017[]; 12 (4 ): e0174523 PMID28380007 show ga BACKGROUND: Influenza virus infection is a major threat to human health. Small interfering RNA (siRNA) is a promising approach for the prevention and treatment of viral infections. In this study, we constructed a series of DNA vector-based short hairpin RNAs (shRNAs) that target various genes of the influenza A virus using the polymerase III U6-RNA promoter to prevent influenza virus infection in vitro and in a mouse model. RESULTS: Three sets of DNA vector-based shRNA, two targeting genes encoding the polymerase acidic protein (PA) and one targeting polymerase basic protein 2 (PB2), efficiently inhibited the replication of influenza virus A/WSN/33(H1N1) in vitro. We also successfully prevented influenza virus A/WSN/33(H1N1) infection in a C57BL/6 mouse model by intratracheal delivery of anti-PB2 shRNA. CONCLUSIONS: Our findings suggest that the PB2-targeting shRNA plasmid showed potential for use as an RNAi-based therapeutic for influenza virus infection. |*RNA Interference [MESH] |Animals [MESH] |Female [MESH] |Influenza A virus/*drug effects/physiology [MESH] |Intubation, Intratracheal [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Orthomyxoviridae Infections/*prevention & control [MESH] |RNA, Small Interfering/administration & dosage/genetics/*pharmacology [MESH] |RNA-Dependent RNA Polymerase/*drug effects [MESH] |RNAi Therapeutics/*methods [MESH] |Viral Proteins/*drug effects [MESH]In vivo inhibition of influenza A virus replication by RNA interferenc(epmc).pdf DeepDyve Pubget Overpricing