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10.1038/srep05573 http://scihub22266oqcxt.onion/10.1038/srep05573 C5381699!5381699!24994517     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2014 ; 4 (ä): ä Nephropedia Template TP {{tp|p=24994517|t=2014. A design principle underlying the paradoxical roles of E3 ubiquitin ligases |pdf=|usr=}}{{24994517}} gab.com Text A design principle underlying the paradoxical roles of E3 ubiquitin ligases JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=24994517 #FOAvip E3 ubiquitin ligases are important cellular components that determine the specificity of proteolysis in the ubiquitin-proteasome system. However, an increasing number of studies have indicated that E3 ubiquitin ligases also participate in transcription. Intrigued by the apparently paradoxical functions of E3 ubiquitin ligases in both proteolysis and transcriptional activation, we investigated the underlying design principles using mathematical modeling. We found that the antagonistic functions integrated in E3 ubiquitin ligases can prevent any undesirable sustained activation of downstream genes when E3 ubiquitin ligases are destabilized by unexpected perturbations. Interestingly, this design principle of the system is similar to the operational principle of a safety interlock device in engineering systems, which prevents a system from abnormal operation unless stability is guaranteed. Twit Text FOAVip A design principle underlying the paradoxical roles of E3 ubiquitin ligases ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=24994517 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24994517 #FOAvip English Wikipedia <ref>{{Cite pmid|24994517}}</ref> A design principle underlying the paradoxical roles of E3 ubiquitin ligases #MMPMID24994517 Lee D; Kim M; Cho KH Sci Rep 2014[]; 4 (ä): ä PMID24994517show ga E3 ubiquitin ligases are important cellular components that determine the specificity of proteolysis in the ubiquitin-proteasome system. However, an increasing number of studies have indicated that E3 ubiquitin ligases also participate in transcription. Intrigued by the apparently paradoxical functions of E3 ubiquitin ligases in both proteolysis and transcriptional activation, we investigated the underlying design principles using mathematical modeling. We found that the antagonistic functions integrated in E3 ubiquitin ligases can prevent any undesirable sustained activation of downstream genes when E3 ubiquitin ligases are destabilized by unexpected perturbations. Interestingly, this design principle of the system is similar to the operational principle of a safety interlock device in engineering systems, which prevents a system from abnormal operation unless stability is guaranteed. äA design principle underlying the paradoxical roles of E3 ubiquitin li(epmc).pdf DeepDyve Pubget Overpricing