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10.1093/ckj/sfx009 http://scihub22266oqcxt.onion/10.1093/ckj/sfx009 C5381234!5381234!28396747     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Kidney+J 2017 ; 10 (2): 282-90 Nephropedia Template TP {{tp|p=28396747|t=2017. Optimization of anti-infective dosing regimens during online haemodiafiltration |pdf=|usr=}}{{28396747}} gab.com Text Optimization of anti-infective dosing regimens during online haemodiafiltration JO: Clin Kidney J http://www.kidney.de/pget.php?&tw=1&pmid=28396747 #FOAvip Online haemodiafiltration (HDF) is increasingly used in clinical practice as a routine intermittent dialysis modality. It is well known that renal impairment and renal replacement therapy can substantially affect the pharmacokinetic behaviour of several drugs. However, surprisingly few data are available on the need for specific dose adjustments during HDF. Due to convection, drug clearance may be increased during HDF as compared with standard haemodialysis. This may be of particular interest in patients undergoing anti-infective therapy, since under-dosing may compromise patient outcomes and promote the emergence of bacterial resistance. Drug clearance during HDF is determined by (i) dialysis characteristics, (ii) drug characteristics and (iii) patient characteristics. In this review, we will discuss these different determinants of drug clearance during HDF and advise on how to adjust the dose of antibacterial, antimycotic and antiviral agents in patients undergoing HDF. In addition, the possible added value of therapeutic drug monitoring is discussed. The review provides guidance for optimization of anti-infective dosing regimens in HDF patients. Twit Text FOAVip Optimization of anti-infective dosing regimens during online haemodiafiltration ????Clin Kidney J http://www.kidney.de/pget.php?&tw=1&pmid=28396747 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28396747 #FOAvip English Wikipedia <ref>{{Cite pmid|28396747}}</ref> Optimization of anti-infective dosing regimens during online haemodiafiltration #MMPMID28396747 Jager NGL; Zandvliet AS; Touw DJ; Penne EL Clin Kidney J 2017[Apr]; 10 (2): 282-90 PMID28396747show ga Online haemodiafiltration (HDF) is increasingly used in clinical practice as a routine intermittent dialysis modality. It is well known that renal impairment and renal replacement therapy can substantially affect the pharmacokinetic behaviour of several drugs. However, surprisingly few data are available on the need for specific dose adjustments during HDF. Due to convection, drug clearance may be increased during HDF as compared with standard haemodialysis. This may be of particular interest in patients undergoing anti-infective therapy, since under-dosing may compromise patient outcomes and promote the emergence of bacterial resistance. Drug clearance during HDF is determined by (i) dialysis characteristics, (ii) drug characteristics and (iii) patient characteristics. In this review, we will discuss these different determinants of drug clearance during HDF and advise on how to adjust the dose of antibacterial, antimycotic and antiviral agents in patients undergoing HDF. In addition, the possible added value of therapeutic drug monitoring is discussed. The review provides guidance for optimization of anti-infective dosing regimens in HDF patients. äOptimization of anti-infective dosing regimens during online haemodiaf(epmc).pdf DeepDyve Pubget Overpricing