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10.1186/s13039-017-0314-8 http://scihub22266oqcxt.onion/10.1186/s13039-017-0314-8 C5381125!5381125!28396696     free     free     free       Mol+Cytogenet 2017 ; 10 (ä): ä Nephropedia Template TP {{tp|p=28396696|t=2017. Is DNA methylation the new guardian of the genome?|pdf=|usr=}}{{28396696}} gab.com Text Is DNA methylation the new guardian of the genome JO: Mol Cytogenet http://www.kidney.de/pget.php?&tw=1&pmid=28396696 #FOAvip Background: It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the ?guardian of the genome.? However, it has been shown that inactivation of p53 does not cause aneuploidy. Another essence of cancer is global DNA hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. Yet, another essence of cancer is excessive use of methionine, resulting in methionine dependence. Methionine dependence is due to possible ?metabolic reprogramming? due to carcinogens, including chemical agents and infectious organisms, such as Helicobacter pylori, that result in altered and excessive transmethylation in cancer cells. Cancer cells appear to have a ?methyl-sink? whereby methyl groups are diverted from DNA. Conclusion: DNA hypomethylation destabilizes the genome, leading to aneuploidy and subsequent selection and speciation into autonomous cancers, leading to the conclusion that DNA methylation is the ?guardian of the genome.? Electronic supplementary material: The online version of this article (doi:10.1186/s13039-017-0314-8) contains supplementary material, which is available to authorized users. Twit Text FOAVip Is DNA methylation the new guardian of the genome ????Mol Cytogenet http://www.kidney.de/pget.php?&tw=1&pmid=28396696 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28396696 #FOAvip English Wikipedia <ref>{{Cite pmid|28396696}}</ref> Is DNA methylation the new guardian of the genome? #MMPMID28396696 Hoffman RM Mol Cytogenet 2017[]; 10 (ä): ä PMID28396696show ga Background: It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the ?guardian of the genome.? However, it has been shown that inactivation of p53 does not cause aneuploidy. Another essence of cancer is global DNA hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. Yet, another essence of cancer is excessive use of methionine, resulting in methionine dependence. Methionine dependence is due to possible ?metabolic reprogramming? due to carcinogens, including chemical agents and infectious organisms, such as Helicobacter pylori, that result in altered and excessive transmethylation in cancer cells. Cancer cells appear to have a ?methyl-sink? whereby methyl groups are diverted from DNA. Conclusion: DNA hypomethylation destabilizes the genome, leading to aneuploidy and subsequent selection and speciation into autonomous cancers, leading to the conclusion that DNA methylation is the ?guardian of the genome.? Electronic supplementary material: The online version of this article (doi:10.1186/s13039-017-0314-8) contains supplementary material, which is available to authorized users. äIs DNA methylation the new guardian of the genome?(epmc).pdf DeepDyve Pubget Overpricing