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10.1186/s12929-017-0329-9 http://scihub22266oqcxt.onion/10.1186/s12929-017-0329-9 C5381059!5381059!28376884     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biomed+Sci 2017 ; 24 (ä): ä Nephropedia Template TP {{tp|p=28376884|t=2017. Cancer immunotherapies targeting the PD-1 signaling pathway |pdf=|usr=}}{{28376884}} gab.com Text Cancer immunotherapies targeting the PD-1 signaling pathway JO: J Biomed Sci http://www.kidney.de/pget.php?&tw=1&pmid=28376884 #FOAvip Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have opened new avenues in cancer immunology. However, the failure of a large subset of cancer patients to respond to these new immunotherapies has led to intensified research on combination therapies and predictive biomarkers. Here we summarize the development of PD-1-blockade immunotherapy and current issues in its clinical use. Twit Text FOAVip Cancer immunotherapies targeting the PD-1 signaling pathway ????J Biomed Sci http://www.kidney.de/pget.php?&tw=1&pmid=28376884 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28376884 #FOAvip English Wikipedia <ref>{{Cite pmid|28376884}}</ref> Cancer immunotherapies targeting the PD-1 signaling pathway #MMPMID28376884 Iwai Y; Hamanishi J; Chamoto K; Honjo T J Biomed Sci 2017[]; 24 (ä): ä PMID28376884show ga Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have opened new avenues in cancer immunology. However, the failure of a large subset of cancer patients to respond to these new immunotherapies has led to intensified research on combination therapies and predictive biomarkers. Here we summarize the development of PD-1-blockade immunotherapy and current issues in its clinical use. äCancer immunotherapies targeting the PD-1 signaling pathway (epmc).pdf DeepDyve Pubget Overpricing