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2017 ; 7
(ä): 46024
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Activation of perineuronal net-expressing excitatory neurons during associative
memory encoding and retrieval
#MMPMID28378772
Morikawa S
; Ikegaya Y
; Narita M
; Tamura H
Sci Rep
2017[Apr]; 7
(ä): 46024
PMID28378772
show ga
Perineuronal nets (PNNs), proteoglycan-rich extracellular matrix structures, are
thought to be expressed around inhibitory neurons and contribute to critical
periods of brain function and synaptic plasticity. However, in some specific
brain regions such as the amygdala, PNNs were predominantly expressed around
excitatory neurons. These neurons were recruited during auditory fear
conditioning and memory retrieval. Indeed, the activation of PNN-expressing
excitatory neurons predicted cognitive performance.