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10.1038/srep46097 http://scihub22266oqcxt.onion/10.1038/srep46097 C5380948!5380948 !28378844     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28378844 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 46097 Nephropedia Template TP {{tp|p=28378844 |t=2017. MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-?B and negatively regulates inflammatory responses |pdf=|usr=}}{{28378844 }} gab.com Text MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF- B and negatively regulates inflammatory responses JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28378844 #FOAvip Activation of NF-?B transcription factor is strictly regulated to prevent excessive inflammatory responses leading to immunopathology. However, it still remains unclear how NF-?B activation is negatively controlled. The PDZ-LIM domain-containing protein PDLIM2 is a nuclear ubiquitin E3 ligase targeting the p65 subunit of NF-?B for degradation, thus terminating NF-?B-mediated inflammation. Using yeast two-hybrid screening, we sought to isolate PDLIM2-interacting proteins that are critical for suppressing NF-?B signaling. Here we identified MKRN2, a RING finger domain-containing protein that belongs to the makorin ring finger protein gene family, as a novel p65 ubiquitin E3 ligase. MKRN2 bound to p65 and promoted the polyubiquitination and proteasome-dependent degradation of p65 through the MKRN2 RING finger domain, thereby suppressing p65-mediated NF-?B transactivation. Notably, MKRN2 and PDLIM2 synergistically promote polyubiquitination and degradation of p65. Consistently, MKRN2 knockdown in dendritic cells resulted in larger amounts of nuclear p65 and augmented production of proinflammatory cytokines in responses to innate stimuli. These results delineate a novel role of MKRN2 in negatively regulating NF-?B-mediated inflammatory responses, cooperatively with PDLIM2. Twit Text FOAVip MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF- B and negatively regulates inflammatory responses ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28378844 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28378844 #FOAvip English Wikipedia <ref>{{Cite pmid|28378844 }}</ref> MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-?B and negatively regulates inflammatory responses #MMPMID28378844 Shin C ; Ito Y ; Ichikawa S ; Tokunaga M ; Sakata-Sogawa K ; Tanaka T Sci Rep 2017[Apr]; 7 (ä): 46097 PMID28378844 show ga Activation of NF-?B transcription factor is strictly regulated to prevent excessive inflammatory responses leading to immunopathology. However, it still remains unclear how NF-?B activation is negatively controlled. The PDZ-LIM domain-containing protein PDLIM2 is a nuclear ubiquitin E3 ligase targeting the p65 subunit of NF-?B for degradation, thus terminating NF-?B-mediated inflammation. Using yeast two-hybrid screening, we sought to isolate PDLIM2-interacting proteins that are critical for suppressing NF-?B signaling. Here we identified MKRN2, a RING finger domain-containing protein that belongs to the makorin ring finger protein gene family, as a novel p65 ubiquitin E3 ligase. MKRN2 bound to p65 and promoted the polyubiquitination and proteasome-dependent degradation of p65 through the MKRN2 RING finger domain, thereby suppressing p65-mediated NF-?B transactivation. Notably, MKRN2 and PDLIM2 synergistically promote polyubiquitination and degradation of p65. Consistently, MKRN2 knockdown in dendritic cells resulted in larger amounts of nuclear p65 and augmented production of proinflammatory cytokines in responses to innate stimuli. These results delineate a novel role of MKRN2 in negatively regulating NF-?B-mediated inflammatory responses, cooperatively with PDLIM2. |Adaptor Proteins, Signal Transducing/metabolism [MESH] |Animals [MESH] |Cell Line [MESH] |Humans [MESH] |Inflammation/*metabolism/*pathology [MESH] |LIM Domain Proteins/metabolism [MESH] |Mice [MESH] |Polyubiquitin/metabolism [MESH] |Protein Binding [MESH] |Protein Subunits/*metabolism [MESH] |Proteolysis [MESH] |RING Finger Domains [MESH] |Ribonucleoproteins/chemistry/deficiency/*metabolism [MESH] |Signal Transduction [MESH] |Transcription Factor RelA/*metabolism [MESH]MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-?B and (epmc).pdf DeepDyve Pubget Overpricing