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10.1155/2017/3485785 http://scihub22266oqcxt.onion/10.1155/2017/3485785 C5380833!5380833!28421193     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2017 ; 2017 (ä): ä Nephropedia Template TP {{tp|p=28421193|t=2017. Molecular Abnormalities Underlying Bone Fragility in Chronic Kidney Disease |pdf=|usr=}}{{28421193}} gab.com Text Molecular Abnormalities Underlying Bone Fragility in Chronic Kidney Disease JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=28421193 #FOAvip Prevention of bone fractures is one goal of therapy for patients with chronic kidney disease-mineral and bone disorder (CKD-MBD), as indicated by the Kidney Disease: Improving Global Outcomes guidelines. CKD patients, including those on hemodialysis, are at higher risk for fractures and fracture-related death compared to people with normal kidney function. However, few clinicians focus on this issue as it is very difficult to estimate bone fragility. Additionally, uremia-related bone fragility has a more complicated pathological process compared to osteoporosis. There are many uremia-associated factors that contribute to bone fragility, including severe secondary hyperparathyroidism, skeletal resistance to parathyroid hormone, and bone mineralization disorders. Uremia also aggravates bone volume loss, disarranges microarchitecture, and increases the deterioration of material properties of bone through abnormal bone cells or excess oxidative stress. In this review, we outline the prevalence of fractures, the interaction of CKD-MBD with osteoporosis in CKD patients, and discuss possible factors that exacerbate the mechanical properties of bone. Twit Text FOAVip Molecular Abnormalities Underlying Bone Fragility in Chronic Kidney Disease ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=28421193 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28421193 #FOAvip English Wikipedia <ref>{{Cite pmid|28421193}}</ref> Molecular Abnormalities Underlying Bone Fragility in Chronic Kidney Disease #MMPMID28421193 Iwasaki Y; Kazama JJ; Fukagawa M Biomed Res Int 2017[]; 2017 (ä): ä PMID28421193show ga Prevention of bone fractures is one goal of therapy for patients with chronic kidney disease-mineral and bone disorder (CKD-MBD), as indicated by the Kidney Disease: Improving Global Outcomes guidelines. CKD patients, including those on hemodialysis, are at higher risk for fractures and fracture-related death compared to people with normal kidney function. However, few clinicians focus on this issue as it is very difficult to estimate bone fragility. Additionally, uremia-related bone fragility has a more complicated pathological process compared to osteoporosis. There are many uremia-associated factors that contribute to bone fragility, including severe secondary hyperparathyroidism, skeletal resistance to parathyroid hormone, and bone mineralization disorders. Uremia also aggravates bone volume loss, disarranges microarchitecture, and increases the deterioration of material properties of bone through abnormal bone cells or excess oxidative stress. In this review, we outline the prevalence of fractures, the interaction of CKD-MBD with osteoporosis in CKD patients, and discuss possible factors that exacerbate the mechanical properties of bone. äMolecular Abnormalities Underlying Bone Fragility in Chronic Kidney Di(epmc).pdf DeepDyve Pubget Overpricing