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10.1158/0008-5472.CAN-16-2958 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-16-2958 C5380518!5380518!28330929     free     free     free       Cancer+Res 2017 ; 77 (7): 1542-7 Nephropedia Template TP {{tp|p=28330929|t=2017. The role of PIAS SUMO E3-ligases in cancer |pdf=|usr=}}{{28330929}} gab.com Text The role of PIAS SUMO E3-ligases in cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28330929 #FOAvip SUMOylation modifies the interactome, localization, activity and lifespan of its target proteins. This process regulates several cellular machineries, including transcription, DNA damage repair, cell-cycle progression and apoptosis. Accordingly, SUMOylation is critical in maintaining cellular homeostasis and its deregulation leads to the corruption of a plethora of cellular processes that contribute to disease states.Among the proteins involved in SUMOylation, the Protein Inhibitor of Activated STAT (PIAS) E3-ligases were initially described as transcriptional co-regulators. Recent findings also indicate that they have a role in regulating protein stability and signaling transduction pathways. PIAS proteins interact with up to 60 cellular partners affecting several cellular processes, most notably immune regulation and DNA repair, but also cellular proliferation and survival. Here we summarize the current knowledge about their role in tumorigenesis and cancer-related processes. Twit Text FOAVip The role of PIAS SUMO E3-ligases in cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28330929 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28330929 #FOAvip English Wikipedia <ref>{{Cite pmid|28330929}}</ref> The role of PIAS SUMO E3-ligases in cancer #MMPMID28330929 Rabellino A; Andreani C; Scaglioni PP Cancer Res 2017[Apr]; 77 (7): 1542-7 PMID28330929show ga SUMOylation modifies the interactome, localization, activity and lifespan of its target proteins. This process regulates several cellular machineries, including transcription, DNA damage repair, cell-cycle progression and apoptosis. Accordingly, SUMOylation is critical in maintaining cellular homeostasis and its deregulation leads to the corruption of a plethora of cellular processes that contribute to disease states.Among the proteins involved in SUMOylation, the Protein Inhibitor of Activated STAT (PIAS) E3-ligases were initially described as transcriptional co-regulators. Recent findings also indicate that they have a role in regulating protein stability and signaling transduction pathways. PIAS proteins interact with up to 60 cellular partners affecting several cellular processes, most notably immune regulation and DNA repair, but also cellular proliferation and survival. Here we summarize the current knowledge about their role in tumorigenesis and cancer-related processes. äThe role of PIAS SUMO E3-ligases in cancer (epmc).pdf DeepDyve Pubget Overpricing